Jean Jakoncic
Brookhaven National Laboratory
71 Papers
185 Citations
Jean Jakoncic is an academic researcher from Brookhaven National Laboratory. The author has contributed to research in topics: Chemistry & Beamline. The author has an hindex of 22, co-authored 62 publications. Previous affiliations of Jean Jakoncic include European Synchrotron Radiation Facility & Joseph Fourier University.
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Papers
Migrastatin analogues target fascin to block tumour metastasis
TL;DR: It is shown that migrastatin analogues target the actin-bundling protein fascin to inhibit its activity, demonstrating that actin cytoskeletal proteins such as fascin can be explored as new molecular targets for cancer treatment, in a similar manner to the microtubule protein tubulin.
Erratum: Migrastatin analogues target fascin to block tumour metastasis
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous work.
Molecular mechanism of fascin function in filopodial formation
Shengyu Yang,Fang-Ke Huang,Jianyun Huang,Shuai Chen,Jean Jakoncic,Alejandra Leo-Macias,Ruben Diaz-Avalos,Lin Chen,J. Jillian Zhang,Xin-Yun Huang +9 more
TL;DR: There are two major actin-binding sites on fascin and there is a concerted conformational changes in fascin from inactive to active states in the process of actin bundling, revealing the molecular mechanism of fascin function in filopodial formation.
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UHRF1 Double Tudor Domain and the Adjacent PHD Finger Act Together to Recognize K9me3-Containing Histone H3 Tail
TL;DR: It is found that the preceding zinc-Cys4 knuckle is indispensable for the PHD finger of UHRF1 to recognize the first four unmodified residues of histone H3 N-terminal tail, which may play a role in establishing and maintaining hist one H3K9 methylation patterns during the cell cycle.
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Regulation of the NaV1.5 cytoplasmic domain by calmodulin
Sandra B. Gabelli,Agedi N. Boto,Victoria Halperin Kuhns,Mario A. Bianchet,Federica Farinelli,Srinivas Aripirala,Jesse B. Yoder,Jean Jakoncic,Gordon F. Tomaselli,L. Mario Amzel +9 more
TL;DR: It is proposed that the structure reported here represents a non-inactivated state of the CTNav, i.e., the state that is poised for activation.