Jean-Frédéric Dubern
University of Nottingham
41 Papers
59 Citations
Jean-Frédéric Dubern is an academic researcher from University of Nottingham. The author has contributed to research in topics: Quorum sensing & Pseudomonas aeruginosa. The author has an hindex of 13, co-authored 32 publications. Previous affiliations of Jean-Frédéric Dubern include Leiden University.
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Papers
Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species
TL;DR: The most recent findings on the biosynthesis and regulation of PQS and other AQs including the discovery of AQs in other bacterial species are summarized.
303
Simultaneous quantitative profiling of N-acyl-L-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS
Catharine A. Ortori,Jean-Frédéric Dubern,Siri Ram Chhabra,Miguel Cámara,Kim R. Hardie,Paul Williams,David A. Barrett +6 more
TL;DR: Application of the LC-MS/MS method showed significant effects of growth medium type on the ratio and the nature of the QSSMs synthesized and the dramatic effect of single, double and triple mutations in the P. aeruginosa QS synthase genes.
189
Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa.
Giordano Rampioni,Giordano Rampioni,Marilena Falcone,Stephan Heeb,Emanuela Frangipani,Emanuela Frangipani,Matthew P. Fletcher,Jean-Frédéric Dubern,Paolo Visca,Livia Leoni,Miguel Cámara,Paul Williams +11 more
TL;DR: In this article, the pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents.
The fitness burden imposed by synthesising quorum sensing signals
Avika Ruparell,Jean-Frédéric Dubern,Cartherine A Ortori,Freya Harrison,Nigel Halliday,Abigail L. Emtage,Mahmoud Ashawesh,Charles A. Laughton,Steve Diggle,Paul Williams,David A. Barrett,Kim R. Hardie +11 more
TL;DR: The data identify the sources of the fitness costs incurred by QSSM producer cells, and indicate that there may be metabolic trade-offs associated with QS signaling that could exert selection on how signaling evolves.
Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections
Yasin Kurmoo,Andrew L. Hook,Daniel Harvey,Jean-Frédéric Dubern,Paul Williams,Stephen P. Morgan,Sergiy Korposh,Morgan R. Alexander +7 more
TL;DR: Long period grating optical fibre sensors incorporated into the lumen of endotracheal tubes are used, to monitor in real time, Pseudomonas aeruginosa surface colonisation and biofilm formation, to reduce the risk of ventilator associated pneumonia.