Jean-Claude Carel
University of Paris
209 Papers
1.2K Citations
Jean-Claude Carel is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Precocious puberty. The author has an hindex of 50, co-authored 203 publications. Previous affiliations of Jean-Claude Carel include French Institute of Health and Medical Research & Paris Diderot University.
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Papers
Beyond the Hormone: Insulin as an Autoimmune Target in Type 1 Diabetes
Vedran Brezar,Jean-Claude Carel,Christian Boitard,Christian Boitard,Christian Boitard,Roberto Mallone,Roberto Mallone,Roberto Mallone +7 more
TL;DR: A unifying scheme will be proposed to show how different aspects of insulin biology may lead to β-cell destruction and may be therapeutically exploited, and a revision of the classical dichotomy between type 1 and type 2 diabetes is proposed.
Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study.
Michelle Rosenzwajg,Randa Salet,Roberta Lorenzon,Nicolas Tchitchek,Alexandra Roux,Claude Bernard,Jean-Claude Carel,Caroline Storey,Michel Polak,Jacques Beltrand,Chloé Amouyal,Agnès Hartemann,Pierre Corbeau,Eric Vicaut,Cecile Bibal,Pierre Bougnères,Tu-Anh Tran,David Klatzmann +17 more
TL;DR: The safety profile at all doses, the dose-dependent effects on Tregs and the observed variability of the Treg response to ld-IL2 in children with newly diagnosed type 1 diabetes call for use of the highest dose in future developments.
Prevalence and clinical characteristics of isolated forms of central precocious puberty: a cohort study at a single academic center.
Carole Harbulot,Soucounda Lessim,Dominique Simon,Laetitia Martinerie,Laetitia Martinerie,Caroline Storey,Emmanuel Ecosse,Nicolas de Roux,Jean-Claude Carel,Jean-Claude Carel,Juliane Léger,Juliane Léger +11 more
TL;DR: The findings of this observational cohort study highlight the need for careful monitoring of the various forms of CPP, and future studies should explore pathophysiological mechanisms, particularly for familial forms.
Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice
Karine Thébault-Baumont,D. Dubois-Laforgue,Patricia Krief,Jean-Paul Briand,Philippe Halbout,Karine Vallon-Geoffroy,Joëlle Morin,Véronique Laloux,Agnès Lehuen,Jean-Claude Carel,Jacques Jami,Sylviane Muller,Christian Boitard +12 more
TL;DR: Proinsulin 2(-/-) NOD mice provide a model to study the role of thymic expression of insulin in susceptibility to diabetes and evidence is given that proins insulin 2 expression leads to silencing of T cells specific for an epitope shared by proinsulin 1 and proinsulus 2 is given.