Jean-Charles Fruchart
Pasteur Institute
479 Papers
7.4K Citations
Jean-Charles Fruchart is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Apolipoprotein B & Lipoprotein. The author has an hindex of 94, co-authored 477 publications. Previous affiliations of Jean-Charles Fruchart include university of lille & Université de Montréal.
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Papers
Measurement of apolipoprotein B concentration in plasma lipoproteins by combining selective precipitation and mass spectrometry.
Laurent Béghin,Nathalie Duhal,Philippe Poulain,Philippe Hauw,B. Lacroix,Jean-Michel Lecerf,Jean-Paul Bonte,Jean-Charles Fruchart,Gérald Luc +8 more
TL;DR: The combination of isopropanol precipitation and the GC/MS method appears to be a precise and reliable method for kinetic and epidemiological studies.
Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha.
Eric Raspé,Hélène Duez,Phillippe Gervois,Catherine Fievet,Jean-Charles Fruchart,Jean-Charles Fruchart,Sandrine Besnard,Jean Mariani,Alan Tedgui,Bart Staels,Bart Staels +10 more
TL;DR: RORα is identified as a transcriptional regulator of apo C-III gene expression, providing a novel, physiological role for RORα1 in the regulation of genes controlling triglyceride metabolism.
Apolipoprotein A-I containing lipoproteins in coronary artery disease
P. Puchois,A. Kandoussi,P. Fievet,J.L. Fourrier,Michel E. Bertrand,Eugen Koren,Jean-Charles Fruchart +6 more
TL;DR: Data support the view that LpA-I might represent the "antiatherogenic" fraction of HDL, and even, when the levels of their total plasma lipids and lipoproteins are normal, atherosclerotic patients are characterized by a different distribution of apo A-I.
Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of β-oxidation
G. Larigauderie,G. Larigauderie,G. Larigauderie,Clarisse Cuaz-Pérolin,Clarisse Cuaz-Pérolin,Clarisse Cuaz-Pérolin,Amena Ben Younes,Christophe Furman,Christophe Furman,Christophe Furman,C. Lasselin,C. Lasselin,C. Lasselin,Corinne Copin,Corinne Copin,Corinne Copin,Michael Jaye,Jean-Charles Fruchart,Jean-Charles Fruchart,Jean-Charles Fruchart,Mustapha Rouis,Mustapha Rouis,Mustapha Rouis +22 more
TL;DR: Results were obtained which suggest that adipophilin elevates cellular lipids by inhibition of β‐oxidation and acyl‐coenzyme’A synthetase and stimulation of long‐chain fatty acid incorporation into triglycerides, consistent with a role for adipophiles in human foam cell formation.