Jean-Charles Fruchart
Pasteur Institute
479 Papers
7.4K Citations
Jean-Charles Fruchart is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Apolipoprotein B & Lipoprotein. The author has an hindex of 94, co-authored 477 publications. Previous affiliations of Jean-Charles Fruchart include university of lille & Université de Montréal.
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Papers
Entry of polyunsaturated fatty acids into the brain: evidence that high-density lipoprotein-induced methylation of phosphatidylethanolamine and phospholipase A2 are involved.
Valérie Magret,Latifa Elkhalil,Françoise Nazih-Sanderson,Françoise Martin,Jean-Marie Bourre,Jean-Charles Fruchart,Christiane Delbart +6 more
TL;DR: The results support the hypothesis of a close relationship between HDL3 binding, PE methylation and PUFA release, and suggest that the PC pool arising from PE could be used as a pathway for the supply of PUFA to the brain.
Selective uptake of cholesteryl esters from high-density lipoprotein-derived LpA-I and LpA-I:A-II particles by hepatic cells in culture.
Franz Rinninger,Tatjana Kaiser,Eberhard Windler,Heiner Greten,Jean-Charles Fruchart,Graciela Castro +5 more
TL;DR: Results may suggest that LpA-I particles of the human plasma HDL fraction may be those lipoproteins which more efficiently deliver CE to the liver via the selective uptake pathway whereas Lp a-I:A-II may play a less important role.
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Liver X Receptor Activation Induces the Uptake of Cholesteryl Esters From High Density Lipoproteins in Primary Human Macrophages
Stephanie Bultel,Lionel Helin,Véronique Clavey,Giulia Chinetti-Gbaguidi,Elena Rigamonti,Morvane Colin,Jean-Charles Fruchart,Bart Staels,Sophie Lestavel +8 more
TL;DR: A new role for LXRs is identified in the control of cholesterol homeostasis in human macrophages through an increased CE uptake from HDL and leads to an increased cholesterol availability to efflux to apoAI and HDL.
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The Orphan Nuclear Receptor Rev-Erb Is a Peroxisome Proliferator-activated Receptor (PPAR) Target Gene and Promotes PPAR -induced Adipocyte Differentiation*
Bart Staels Mandrup,Jean-Charles Fruchart,Philippe Gervois,Fabrice Soncin,Susanne Duguay,Torben Helledie,Ngoc Vu-Dac,Coralie Fontaine,Guillaume Dubois,Yannick Duguay,Susanne Mandrup,Jamila Fruchart-Najib,Bart Staels +12 more
- 01 Jan 2003
TL;DR: In this article, the authors cite 57 references, 38 of which can be accessed free at http://www.jbc.org/content/278/39/37672.full.
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Reducing residual vascular risk in patients with atherogenic dyslipidemia: Where do we go from here?
TL;DR: The ACCORD Lipid trial demonstrated that macrovascular RvR, high in Type 2 diabetes mellitus, was decreased after the addition of fenofibrate in patients with AD, and ongoing trials will establish whether targeting low HDL‑C with niacin reduces R vR in high‑risk patients.
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