Jean B. Bertoldo
Martin Luther University of Halle-Wittenberg
9 Papers
26 Citations
Jean B. Bertoldo is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Tyrosine & Druggability. The author has an hindex of 5, co-authored 9 publications. Previous affiliations of Jean B. Bertoldo include Universidade Federal de Santa Catarina & University of Cambridge.
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Papers
Chemo- and Regioselective Lysine Modification on Native Proteins.
Maria João Matos,Bruno L. Oliveira,Nuria Martinez-Saez,Ana Guerreiro,Pedro M. S. D. Cal,Jean B. Bertoldo,M. Maneiro,Elizabeth R. Perkins,Julie Howard,Michael J. Deery,Justin M. Chalker,Francisco Corzana,Gonzalo Jiménez-Osés,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +14 more
TL;DR: It is shown that a protein–antibody conjugate bearing a site-specifically installed fluorophore at lysine could be used for selective imaging of apoptotic cells and detection of Her2+ cells, respectively and may be generally used for accessing diverse, well-defined protein conjugates for basic biology and therapeutic studies.
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The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer.
Simon Müller,Nadine Bley,Bianca Busch,Markus Glaß,Marcell Lederer,Claudia Misiak,Tommy Fuchs,Alice Wedler,Jacob Haase,Jean B. Bertoldo,Patrick Michl,Stefan Hüttelmaier +11 more
TL;DR: It is revealed that IGF2BP1 is a post-transcriptional enhancer of the E2F-driven hallmark in solid cancers, and the small molecule BTYNB disrupts this enhancer function by impairing IGF2 BP1-RNA association.
Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells
Pedro M. S. D. Cal,Pedro M. S. D. Cal,Florian Sieglitz,Fábio M. F. Santos,Cátia Parente Carvalho,Ana Guerreiro,Jean B. Bertoldo,Uwe Pischel,Pedro M. P. Gois,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +10 more
TL;DR: The design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY) dyes and their use for site-selective labelling of Annexin V maintained function and fluorescence as demonstrated by the targeted detection of apoptotic cells.
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Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
Philip R. Lindstedt,Francesco A. Aprile,Maria João Matos,Michele Perni,Jean B. Bertoldo,Barbara Bernardim,Quentin Peter,Gonzalo Jiménez-Osés,Tuomas P. J. Knowles,Christopher M. Dobson,Francisco Corzana,Michele Vendruscolo,Gonçalo J. L. Bernardes +12 more
TL;DR: It is shown that this regioselective conjugation augments in vitro the anti-aggregation activity of Hsp70 in a synergistic manner, and also displays in vivo an enhanced suppression of α-synuclein aggregation and its associated toxicity in a Caenorhabditis elegans model of PD.
A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases
Jean B. Bertoldo,Jean B. Bertoldo,Tiago Rodrigues,Lavinia Dunsmore,Francesco A. Aprile,Marta C. Marques,Leonardo Astolfi Rosado,Omar Boutureira,Thomas Steinbrecher,Woody Sherman,Francisco Corzana,Hernán Terenzi,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +13 more
TL;DR: The identification of a water-mediated Cys-Cys non-covalent motif that modulates accessibility of the protein tyrosine phosphatase A (PtpA) catalytic pocket provides insight into the known resistance of Mtb PtpA to the oxidative conditions that prevail within an infected host macrophage.
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