Jayant Bhandari
McMaster University
12 Papers
27 Citations
Jayant Bhandari is an academic researcher from McMaster University. The author has contributed to research in topics: Allosteric modulator & Dopamine receptor D2. The author has an hindex of 6, co-authored 11 publications.
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Papers
Brain Targeting of a Water Insoluble Antipsychotic Drug Haloperidol via the Intranasal Route Using PAMAM Dendrimer.
Yogesh K. Katare,Ritesh Daya,Christal Sookram Gray,Roger E. Luckham,Jayant Bhandari,Abhay Singh Chauhan,Ram K. Mishra +6 more
TL;DR: The potential of dendrimer in improving the delivery of water insoluble drugs to brain is demonstrated by showing significantly higher distribution of haloperidol in the brain and plasma compared to a control formulation of hal operidol administered via intraperitoneal injection.
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Haloperidol-loaded intranasally administered lectin functionalized poly(ethylene glycol)-block-poly(D,L)-lactic-co-glycolic acid (PEG-PLGA) nanoparticles for the treatment of schizophrenia.
Justin E. Piazza,Todd Hoare,Luke Molinaro,Kristen Terpstra,Jayant Bhandari,P. Ravi Selvaganapathy,Bhagwati P. Gupta,Ram K. Mishra +7 more
TL;DR: This formulation demonstrates promise in the reduction of the drug dose necessary to produce a therapeutic effect with antipsychotic drugs for the treatment of schizophrenia by demonstrating minimal drug leakage and the potential for the efficient drug transport to the targeted brain tissue.
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Intranasal delivery of antipsychotic drugs.
Yogesh K. Katare,Justin E. Piazza,Jayant Bhandari,Ritesh Daya,Kosalan Akilan,Madeline J. Simpson,Todd Hoare,Ram K. Mishra +7 more
TL;DR: If limitations of low aqueous solubility of antipsychotic drugs can be overcome and non-toxic formulations used, IN delivery will gain more importance moving forward given the inherent benefits of IN delivery in comparison to other methods.
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Effects of the Dopamine D2 Allosteric Modulator, PAOPA, on the Expression of GRK2, Arrestin-3, ERK1/2, and on Receptor Internalization
Dipannita Basu,Yuxin Tian,Jayant Bhandari,Jian Ru Jiang,Patricia Hui,Rodney L. Johnson,Ram K. Mishra +6 more
TL;DR: The objectives of this study were to decipher the in vivo effects of chronic PAOPA administration on D2 receptor regulatory and downstream molecules, including GRK2, arrestin-3 and extracellular receptor kinase (ERK) 1/2.
Effects of MK-801 treatment across several pre-clinical analyses including a novel assessment of brain metabolic function utilizing PET and CT fused imaging in live rats.
TL;DR: Insight is provided on the effectiveness of the MK-801 pre-clinical model of schizophrenia and the optimal regimen to model schizophrenia and PET/CT fused imaging offers a highly translatable tool to assess hypo- and hyperfrontality in live animals.
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