Jay S. Wright
University of Michigan
14 Papers
31 Citations
Jay S. Wright is an academic researcher from University of Michigan. The author has contributed to research in topics: Chemistry & Aryl. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Jay S. Wright include Durham University.
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Papers
Iridium-Catalysed C-H Borylation of Heteroarenes: Balancing Steric and Electronic Regiocontrol.
TL;DR: This review will survey the borylation of heteroarenes, focusing on the influence of steric and electronic effects on regiochemical outcome and, by linking to current mechanistic understandings, will provide insights to what is currently possible and where further developments are required.
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Copper-Mediated Late-stage Radiofluorination: Five Years of Impact on Pre-clinical and Clinical PET Imaging.
Jay S. Wright,Tanpreet Kaur,Sean Preshlock,Sean S. Tanzey,Wade Winton,Liam S. Sharninghausen,Nicholas Wiesner,Allen F. Brooks,Melanie S. Sanford,Peter J. H. Scott +9 more
TL;DR: Examination of proof-of-concept, preclinical, and in-human imaging studies of new and established imaging agents containing aromatic C– 18 F bonds synthesized with CMRF finds it has significantly expanded the chemical space accessible to fluorine-18 radiolabeling with production methods that can meet the regulatory requirements for use in Nuclear Medicine.
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Sequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes
Jay S. Wright,Liam S. Sharninghausen,Sean Preshlock,Allen F. Brooks,Melanie S. Sanford,Peter J. H. Scott +5 more
TL;DR: In this article, a sequential Ir/Cu-mediated process for the meta-selective C-H radiofluorination of (hetero)arene substrates was described.
24
SNAr Radiofluorination with In Situ Generated [18F]Tetramethylammonium Fluoride.
So Jeong Lee,So Jeong Lee,María T Morales-Colón,Allen F. Brooks,Jay S. Wright,Katarina J. Makaravage,Peter J. H. Scott,Melanie S. Sanford +7 more
TL;DR: In this article, a method for the nucleophilic radiofluorination of (hetero)aryl chlorides, triflates, and nitroarenes using a combination of [18F]KF·K2.2 and Me4NHCO3 was proposed.
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