Jay Penney
Massachusetts Institute of Technology
8 Papers
8 Citations
Jay Penney is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Neurodegeneration & Microglia. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Jay Penney include Picower Institute for Learning and Memory.
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Papers
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Yuan-Ta Lin,Jinsoo Seo,Jinsoo Seo,Fan Gao,Heather M. Feldman,Hsin-Lan Wen,Jay Penney,Jay Penney,Hugh P. Cam,Hugh P. Cam,Elizabeta Gjoneska,Elizabeta Gjoneska,Waseem K. Raja,Waseem K. Raja,Jemmie Cheng,Jemmie Cheng,Richard Rueda,Oleg Kritskiy,Fatema Abdurrob,Zhuyu Peng,Blerta Milo,Chung Jong Yu,Sara Elmsaouri,Dilip Dey,Tak Ko,Bruce A. Yankner,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: Consistently, converting APOE4 to APOE3 in brain cell types from sAD iPSCs was sufficient to attenuate multiple AD-related pathologies and establishes a reference for human cell-type-specific changes associated with theAPOE4 variant.
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HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease
Ping-Chieh Pao,Ping-Chieh Pao,Debasis Patnaik,L. Ashley Watson,L. Ashley Watson,Fan Gao,Fan Gao,Fan Gao,Ling Pan,Ling Pan,Jun Wang,Jun Wang,Chinnakkaruppan Adaikkan,Chinnakkaruppan Adaikkan,Jay Penney,Jay Penney,Hugh P. Cam,Hugh P. Cam,Wen-Chin Huang,Wen-Chin Huang,Lorena Pantano,Lorena Pantano,Audrey Lee,Audrey Lee,Alexi Nott,Alexi Nott,Alexi Nott,Trongha X. Phan,Trongha X. Phan,Elizabeta Gjoneska,Elizabeta Gjoneska,Elizabeta Gjoneska,Sara Elmsaouri,Sara Elmsaouri,Stephen J. Haggarty,Li-Huei Tsai,Li-Huei Tsai +36 more
TL;DR: It is shown that HDAC1 modulates OGG1-initated 8-oxoguanine (8-oxoG) repair in the brain, and pharmacological activation ofHDAC1 alleviates the deleterious effects of 8-OxoG in aged wild-type and 5XFAD mice.
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.
Jinsoo Seo,Jinsoo Seo,Oleg Kritskiy,L. Ashley Watson,L. Ashley Watson,Scarlett J. Barker,Scarlett J. Barker,Dilip Dey,Waseem K. Raja,Waseem K. Raja,Yuan-Ta Lin,Yuan-Ta Lin,Tak Ko,Sukhee Cho,Jay Penney,Jay Penney,M. Catarina Silva,Steven D. Sheridan,Diane Lucente,James F. Gusella,Bradford C. Dickerson,Stephen J. Haggarty,Li-Huei Tsai +22 more
TL;DR: A crucial role is demonstrated for p25/Cdk5 in mediating tau-associated pathology and inhibition of this kinase can remedy neurodegenerative processes in the presence of pathogenic tau mutation.
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Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Nader Morshed,William T. Ralvenius,William T. Ralvenius,Alexi Nott,L. Ashley Watson,L. Ashley Watson,Felicia H. Rodriguez,Leyla Anne Akay,Leyla Anne Akay,Brian A. Joughin,Ping-Chieh Pao,Ping-Chieh Pao,Jay Penney,Jay Penney,Lauren LaRocque,Diego Mastroeni,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai,Forest M. White +19 more
TL;DR: A shared response involving Siglec‐F which was upregulated on a subset of reactive microglia in AD is identified and points to an important role for mouse SigleC‐F and human SigLec‐8 in regulating microglial activation during neurodegeneration.
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A Developmental Switch in Microglial HDAC Function.
Hansruedi Mathys,Hansruedi Mathys,Jay Penney,Jay Penney,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +6 more
TL;DR: The epigenetic mechanisms controlling microglia functions are largely unknown but surprising and distinct effects of deleting the epigenetic regulators HDAC1 and HDAC2 during microglial development versus during the course of neurodegeneration are uncovered.
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