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Fundamentals of Clinical Psychopharmacology, Fourth Edition

Depressive disorders are common, debilitating diseases. Current treatments on the market are unsuccessful for many patients, have high rates of remission, and many side effects. After finding that the D1-D2 dopamine receptor complex is upregulated in post-mortem patients that suffered from major depressive disorder, our lab developed a peptide drug that interferes with this complex to serve as an antidepressant drug. Our lab has previously tested the efficacy of the D1-D2 interfering peptide through intracranial administration and intranasal administration. A major component of preclinical drug testing is finding the optimal method of administration. In this study, we find that the peptide has antidepressantlike effects compared to saline in rats in the forced swimming test at doses greater than 1.5nmol/g. These findings are an important step in the preclinical research of a peptide with antidepressant-like effects.

Intravenous Delivery of a D1-D2 Interfering Peptide with Antidepressant-like Effects

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Intravenous Delivery of a D1-D2 Interfering Peptide with Antidepressant-like Effects