Javier Tapial
Pompeu Fabra University
4 Papers
Javier Tapial is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Alternative splicing & Biology. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Javier Tapial include European Bioinformatics Institute.
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Papers
A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains
Manuel Irimia,Manuel Irimia,Robert J. Weatheritt,Jonathan D. Ellis,Neelroop N. Parikshak,Thomas Gonatopoulos-Pournatzis,Mariana Babor,Mathieu Quesnel-Vallières,Javier Tapial,Bushra Raj,Dave O'Hanlon,Miriam Barrios-Rodiles,Michael J.E. Sternberg,Sabine P. Cordes,Frederick P. Roth,Jeffrey L. Wrana,Jeffrey L. Wrana,Daniel H. Geschwind,Benjamin J. Blencowe +18 more
TL;DR: The results reveal a highly conserved program of dynamic microexon regulation associated with the remodeling of protein-interaction networks during neurogenesis, the misregulation of which is linked to autism.
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An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms.
Javier Tapial,Javier Tapial,Kevin C.H. Ha,Timothy Sterne-Weiler,Andre Gohr,Andre Gohr,Ulrich Braunschweig,Antonio Hermoso-Pulido,Antonio Hermoso-Pulido,Mathieu Quesnel-Vallières,Jon Permanyer,Jon Permanyer,Reza Sodaei,Reza Sodaei,Yamile Marquez,Yamile Marquez,Luca Cozzuto,Luca Cozzuto,Xinchen Wang,Melisa Gomez-Velazquez,Teresa Rayon,Miguel Manzanares,Julia Ponomarenko,Julia Ponomarenko,Benjamin J. Blencowe,Manuel Irimia,Manuel Irimia +26 more
TL;DR: VastDB provides readily accessible quantitative information on the inclusion levels and functional associations of AS events detected in RNA-seq data from diverse vertebrate cell and tissue types, as well as developmental stages, and reveals extensive new intergenic and intragenic regulatory relationships among different classes of AS and previously unknown and conserved landscapes of tissue-regulated exons.
Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians
Jordi Solana,Manuel Irimia,Salah Ayoub,Marta Rodriguez Orejuela,Vera Zywitza,Marvin Jens,Javier Tapial,Debashish Ray,Quaid Morris,Timothy P. Hughes,Benjamin J. Blencowe,Nikolaus Rajewsky +11 more
TL;DR: It is shown that functional antagonism between CELF and MBNL factors directly controls stem cell-specific AS in planarians, placing the origin of this regulatory mechanism at the base of Bilaterians.
Computational Analysis of Alternative Splicing Using VAST-TOOLS and the VastDB Framework.
Andre Gohr,Federica Mantica,Antonio Hermoso-Pulido,Javier Tapial,Yamile Marquez,Manuel Irimia +5 more
- 01 Jan 2022
TL;DR: The computational VastDB framework is created, which comprises a series of complementary software and resources that are especially designed to aid biomedical researchers without a strong computational background, to facilitate AS research.