Javier Capdevila
Salk Institute for Biological Studies
17 Papers
182 Citations
Javier Capdevila is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Wnt signaling pathway & Apical ectodermal ridge. The author has an hindex of 12, co-authored 16 publications.
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Papers
Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud
Mineko Kengaku,Mineko Kengaku,Javier Capdevila,Concepción Rodríguez-Esteban,Jennifer de la Peña,Randy L. Johnson,Juan Carlos Izpisua Belmonte,Clifford J. Tabin +7 more
TL;DR: Two related Wnt genes elicit distinct responses in the same tissues by using different intracellular pathways that affect the Wnt7a-regulated dorsoventral polarity of the limb.
441
WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo
Yasuhiko Kawakami,Javier Capdevila,Dirk Büscher,Tohru Itoh,Concepcion Rodriguez Esteban,Juan Carlos Izpisua Belmonte +5 more
TL;DR: Three WNT factors signaling through beta-catenin act as key regulators of the FGF-8/FGF-10 loop and control both limb initiation and AER induction in the vertebrate embryo.
378
Mechanisms of left-right determination in vertebrates.
TL;DR: This review highlights the need to understand more fully the rationale behind the continued use of laser-spot assisted, 3D image analysis in the treatment of central nervous system disease.
325
Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1.
Tohru Tsukui,Javier Capdevila,Koji Tamura,Pilar Ruiz-Lozano,Concepción Rodríguez-Esteban,Sayuri Yonei-Tamura,Jorge Magallon,Roshantha A.S. Chandraratna,Kenneth R. Chien,Bruce Blumberg,Bruce Blumberg,Ronald M. Evans,Juan Carlos Izpisua Belmonte +12 more
TL;DR: It is demonstrated that retinoic acid controls Lefty-1 expression in a pathway downstream or parallel to Shh, and evidence that RA controls left-right development across vertebrate species is provided.
283
Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo.
Concepción Rodríguez-Esteban,Javier Capdevila,Yasuhiko Kawakami,Juan Carlos Izpisua Belmonte +3 more
TL;DR: A Wnt/beta-catenin pathway controls Nodal expression in and around Hensen's node, without affecting the upstream regulators Sonic hedgehog, Car and Fibroblast Growth Factor 8.