Javier Bartroli
42 Papers
357 Citations
Javier Bartroli is an academic researcher. The author has contributed to research in topics: Alkyl & Ring (chemistry). The author has an hindex of 14, co-authored 42 publications.
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Papers
New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones
Javier Bartroli,Enric Turmo,Mònica Algueró,E. Boncompte,Maria L. Vericat,Lourdes Conte,Joaquim Ramis,Manuel Merlos,Julian Garcia-Rafanell,Javier Forn +9 more
TL;DR: In vitro 20 was superior to fluconazoles, itraconazole, SCH-42427, and TAK-187 and roughly similar to voriconazole and ER-30346, and in vivo 20 showed excellent protection levels in an immunocompromised rat model of disseminated aspergillosis.
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Synthesis and Structure−Activity Relationship of a New Series of COX-2 Selective Inhibitors: 1,5-Diarylimidazoles
Carmen Almansa,José Alfón,Alberto Fernández de Arriba,F. L. Cavalcanti,Ignasi Escamilla,L. A. Gomez,Agusti Miralles,Robert Soliva,Javier Bartroli,Elena Carceller,Manuel Merlos,Julian Garcia-Rafanell +11 more
TL;DR: Modification of all the positions of two regioisomeric imidazole cores led to the identification of 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide (UR-8880, 51f) as the best candidate, which is now undergoing Phase I clinical trials.
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New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol
Javier Bartroli,Enric Turmo,Mònica Algueró,E. Boncompte,Maria L. Vericat,Lourdes Conte,Joaquim Ramis,Manuel Merlos,Julian Garcia-Rafanell,Javier Forn +9 more
TL;DR: The nature and substitution of the amide portion was systematically modified in search of improved antifungal activity, especially against filamentous fungi and it was proven that only an orthogonal orientation of the phenyl ring yields bioactive products.
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[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Elena Carceller,Manuel Merlos,Marta Giral,Dolors Balsa,Carmen Almansa,Javier Bartroli,Julian Garcia-Rafanell,J. Forn +7 more
TL;DR: Optimum structure 19 (UR-12592) incorporating a (5-methyl-3-pyridyl)methyl radical displayed an unique dual activity inhibiting both PAF-induced effects and H1 antihistamine activity, and showed itself to be devoid of CNS depressant effects.
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