Jason L. Scragg
University of Leeds
48 Papers
302 Citations
Jason L. Scragg is an academic researcher from University of Leeds. The author has contributed to research in topics: Heme oxygenase & Voltage-dependent calcium channel. The author has an hindex of 20, co-authored 47 publications.
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Papers
Testosterone is a potent inhibitor of L-type Ca2+ channels
TL;DR: The data indicate that testosterone acts like widely prescribed antihypertensive dihydropyridines to reduce Ca(2+) influx into vascular smooth muscle and so promote vasodilation, likely to account for its beneficial cardiovascular actions.
165
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.
Anna Whitehead,Fynn N. Krause,Amy Moran,Amanda D. V. MacCannell,Jason L. Scragg,Ben D. McNally,Edward Boateng,Steven A. Murfitt,Samuel Virtue,John Wright,Jack Garnham,Graeme Davies,James Dodgson,Jürgen E. Schneider,Andrew J. Murray,Christopher Church,Antonio Vidal-Puig,Klaus K. Witte,Julian L. Griffin,Lee D. Roberts +19 more
TL;DR: This article identified 3-methyl-2-oxovaleric acid, 5-oxoproline, and β-hydroxyisobutyric acid as small molecule metabokines synthesized in browning adipocytes and secreted via monocarboxylate transporters.
Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1
Mark L. Dallas,John P. Boyle,Carol J. Milligan,Rachael Sayer,Talitha L Kerrigan,Connor McKinstry,Peiyuan Lu,Jamel Mankouri,Mark Harris,Jason L. Scragg,Hugh A. Pearson,Chris Peers +11 more
TL;DR: The results provide a novel mechanism to account for the neuroprotective effects of CO against oxidative apoptosis, which has potential for therapeutic exploitation to provide neuronal protection in situations of oxidative stress.
91
Modulation of Ion Channels by Hydrogen Sulfide
TL;DR: This article reviews the numerous, yet diverse, types of ion channels now reported to be regulated by H(2)S, and determines the mechanisms by which H( 2)S regulates ion channels, as well as other target proteins.
89
Heme oxygenase-1 protects against Alzheimer’s amyloid- β 1-42 -induced toxicity via carbon monoxide production
Nishani T. Hettiarachchi,Mark L. Dallas,Moza M. Al-Owais,Heledd H. Griffiths,Nigel M. Hooper,Jason L. Scragg,John P. Boyle,Chris Peers +7 more
TL;DR: It is indicated that HO-1 protects against Aβ toxicity via production of CO, and a novel, beneficial effect of CO is provided which adds to its growing potential as a therapeutic agent.