Jason DeFuria
Boston University
5 Papers
37 Citations
Jason DeFuria is an academic researcher from Boston University. The author has contributed to research in topics: Proinflammatory cytokine & T cell. The author has an hindex of 4, co-authored 5 publications.
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Papers
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
Jason DeFuria,Anna C. Belkina,Madhumita Jagannathan-Bogdan,Jennifer E. Snyder-Cappione,Jordan Carr,Yanina R. Nersesova,Douglas Markham,Katherine J. Strissel,Amanda A. Watkins,Min Zhu,Jessica Allen,Jacqueline Bouchard,Gianluca Toraldo,Ravi Jasuja,Martin S. Obin,Marie E. McDonnell,Caroline M. Apovian,Gerald V. Denis,Barbara S. Nikolajczyk +18 more
TL;DR: The conclusion that B cells are critical regulators of inflammation in T2D due to their direct ability to promote proinflammatory T-cell function and secrete a proinflammatory cytokine profile is supported.
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Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production.
Blanche C. Ip,Nicholas A. Cilfone,Anna C. Belkina,Jason DeFuria,Madhumita Jagannathan-Bogdan,Min Zhu,Ramya Kuchibhatla,Marie E. McDonnell,Qiang Xiao,Thomas B. Kepler,Caroline M. Apovian,Douglas A. Lauffenburger,Barbara S. Nikolajczyk +12 more
TL;DR: The authors hypothesized that cytokine profiles from circulating T cells identify T cell subsets and T cell cytokines that define T2DM-associated inflammation and identified dominant sources of T cell inflammation in humans.
B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation
Min Zhu,Anna C. Belkina,Jason DeFuria,Jordan Carr,Thomas E. Van Dyke,Robert Gyurko,Barbara S. Nikolajczyk +6 more
TL;DR: Data show that fundamentally different mechanisms regulate PD in lean and obese hosts, with B cells able to promote PD only if the hosts are “primed” by obesity, which justifies more intense analysis of obesity‐associated changes in B cells that predispose PD in human T2D.
45
•Journal Article
B cells support a dominant Th17 cytokine signature in type 2 diabetes (HEM4P.255)
Anna C. Belkina,Jason DeFuria,Madhumita Jagannathan-Bogdan,Brooke R. Hasson,Ramya Kuchibhatla,Marie E. McDonnell,Caroline M. Apovian,Nawfal W. Istfan,Qiang Xiao,Barbara S. Nikolajczyk +9 more
TL;DR: It is concluded that human B cell co-stimulation broadly supports Th17 cells, which in turn stimulate lymphocytes (but not monocytes) to produce the classical diabetogenic cytokine TNFα.
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Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production
Blanche C. Ip,Anna C. Belkina,Jason DeFuria,Madhumita Jagannathan-Bogdan,Min Zhu,Ramya Kuchibhatla,Marie E. McDonnell,Qiang Xiao,Thomas B. Kepler,Caroline M. Apovian,Barbara S. Nikolajczyk,Nicholas A. Cilfone,Douglas A. Lauffenburger +12 more
- 01 Nov 2015
TL;DR: It was hypothesized that cytokine profiles from circulating T cells identify T cell subsets and T cell cytokines that define T2DM‐associated inflammation.