https://pure.bond.edu.au/ws/files/27297244/Cochrane_acute_respiratory_infections_group.pdf

Cochrane acute respiratory infections group's stakeholder engagement project identified systematic review priority areas

Cochrane primarily aims to systematically review trials of effectiveness that are important to inform clinical decisions. Editorial groups support authors to achieve high-quality reviews and prioritise review proposals in their clinical domain that are submitted or elicited. Prioritising proposals requires two approaches, identifying (1) clinical practises for which the evidence of effectiveness is uncertain and (2) interventions in which there are trials of effectiveness (especially randomised controlled trials (RCTs)) not systematically reviewed. This study addresses this second approach for the Cochrane Acute Respiratory Infections Group (CARIG) in order to identify RCTs of acute respiratory infections that have not been systematically reviewed. We exported, on the 9th of September 2014, and then compared the group’s trials register of RCTs against a list of current Cochrane ARI (systematic) Reviews to identify gaps in topics (the same intervention and health condition) where completed trials have not been systematically reviewed. We assigned a principle intervention and health condition to each of 157 Cochrane reviews (CRs) and 5393 RCTs. A majority of topics had been systematically reviewed; however, a substantial number (2174 or 41%) of RCTs were not included in any review. The topic that had been systematically reviewed the most was antibiotic vs placebo for pneumonia with 11 CRs and 205 RCTs. The topic that was the subject of most RCTs was vaccination for influenza with 525 RCTs and 6 CRs. Also, 6 CRs had no RCTs (‘empty reviews’). We identified many RCT topics that have not been systematically reviewed. They need to be addressed in a separate process to establish their priority to clinicians.

/pdf/determining-the-gaps-between-cochrane-reviews-and-trials-of-2ltpd5in38.pdf

Determining the gaps between Cochrane reviews and trials of effectiveness of interventions for acute respiratory infections: an audit.

Objective: Wet cough is one of the most common pathologies in the world affecting nearly 12% of the world
 population. Being a multifactorial disease, involving initially viral infection, followed by bacterial secondary superinfection,
 damage to the throat mucosa, production of sticky mucus, and poor local immunity, there is currently no effective drug
 available. We conceived VB-Gy, an osmotically active filmogen solution, capable of cleaning the infected surface of all
 contaminants topically present, and of preparing a favorable ground for healing. The efficacy and safety of VB-Gy is
 assessed through a clinical trial, vs. saline solution as comparator product.
Methods: The study was a multi-centric, randomized, placebo-controlled, double-blind trial on patients suffering
 from wet cough. The study involved 39 in the test product group and 15 patients in the comparator group, each patient
 applying 3-4 sprays of investigational product 4-5 times per day, over a maximum period of 15 days. The effects on
 wet cough severity, frequency, chest discomfort, as well as on throat pain, irritation, requirement for antibiotics, and
 answers to Leicester cough questionnaire for quality of life, were evaluated.
Results: Although regular and frequent use of saline solution spray helped reduce wet cough symptoms
 noticeably, the test product induced very fast and nearly total regression of all clinical signs without any side effects,
 with statistically highly significant difference compared to placebo comparator and baseline data.
Conclusion: Treating wet cough requires a multi-target, cell-friendly, and safe approach to obtain not only
 symptomatic but also curative relief. VB-Gy is a completely new generation of nearly instant, safe, and multi-target
 therapeutic approach of treating various topical infections.

/pdf/a-new-generation-of-throat-cleaning-and-healing-filmogen-54tkyveegg.pdf

A New Generation of Throat Cleaning and Healing Filmogen Solution for the Treatment of Productive (Wet) Cough

https://pure.bond.edu.au/ws/files/28777657/AM_The_TRIP_database_showed_most_Acute_Respiratory_Infections.pdf

The TRIP database showed most Acute Respiratory Infections questions were already addressed by Cochrane reviews

Priority setting for Cochrane Review Groups.

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Determining the gaps between Cochrane reviews and trials of effectiveness of interventions for acute respiratory infections: an audit.