Janos Groh
University of Würzburg
44 Papers
54 Citations
Janos Groh is an academic researcher from University of Würzburg. The author has contributed to research in topics: Myelin & Neuroinflammation. The author has an hindex of 17, co-authored 32 publications.
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Papers
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging
Tuğberk Kaya,Nicola Mattugini,Lu Liu,Hao Ji,Ludovico Cantuti-Castelvetri,Jianping Wu,Martina Schifferer,Janos Groh,Rudolf Martini,Simon Besson-Girard,Seiji Kaji,Arthur Liesz,Ozgun Gokce,Mikael Simons +13 more
TL;DR: In this article , the authors used single-cell RNA-sequencing to identify interferon (IFN)-responsive oligodendrocytes, which localize in proximity to CD8 + T cells in aging white matter.
Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline
Janos Groh,Konrad Knöpper,Panagiota Arampatzi,Xidi Yuan,Lena Lößlein,Antoine-Emmanuel Saliba,Wolfgang Kastenmüller,Rudolf Martini +7 more
- 01 Apr 2021
TL;DR: It is shown that cytotoxic CD8+ T cells accumulate in the central nervous system during normal aging, leading to axonal damage and contributing to age-related cognitive and motor decline.
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Fingolimod and Teriflunomide Attenuate Neurodegeneration in Mouse Models of Neuronal Ceroid Lipofuscinosis
TL;DR: Clinical approved immune modulators such as fingolimod and teriflunomide may be suitable to attenuate progression of CLN1 and CLN3 disease and, possibly, other orphan diseases with pathogenically relevant neuroinflammation.
55
Neuroinflammation by Cytotoxic T-Lymphocytes Impairs Retrograde Axonal Transport in an Oligodendrocyte Mutant Mouse
Chi Wang Ip,Antje Kroner,Janos Groh,Marianne Huber,Dennis Klein,Irene Spahn,Ricarda Diem,Sarah K. Williams,Klaus-Armin Nave,Julia M. Edgar,Rudolf Martini +10 more
TL;DR: It is found that fluorogold stereotactically injected into the colliculus superior led to significantly reduced retrograde axonal transport in retina ganglion cell axons and an accumulation of mitochondria in the juxtaparanodal axonal swellings, indicative for a disturbed axonal Transport.
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Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury.
Chi Wang Ip,Ioannis U. Isaias,Burak B. Kusche-Tekin,Dennis Klein,Janos Groh,Aet O'Leary,Susanne Knorr,Takahiro Higuchi,James B. Koprich,Jonathan M. Brotchie,Klaus V. Toyka,Andreas Reif,Jens Volkmann +12 more
TL;DR: The findings suggest that upon peripheral nerve injury reduced torsinA concentration and environmental stressors may act in concert in causing the central motor network dysfunction of DYT1 dystonia.