Janneke Witte-Bouma
Erasmus University Rotterdam
23 Papers
31 Citations
Janneke Witte-Bouma is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Endochondral ossification & Mesenchymal stem cell. The author has an hindex of 9, co-authored 20 publications. Previous affiliations of Janneke Witte-Bouma include Erasmus University Medical Center.
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Papers
Selective laser melting porous metallic implants with immobilized silver nanoparticles kill and prevent biofilm formation by methicillin-resistant Staphylococcus aureus
Ingmar A.J. van Hengel,Martijn Riool,Lidy E. Fratila-Apachitei,Janneke Witte-Bouma,Eric Farrell,Amir A. Zadpoor,Sebastian A. J. Zaat,Iulian Apachitei +7 more
TL;DR: Rationally designed SLM porous implants outperformed solid implants with similar dimensions undergoing the same biofunctionalization treatment, and included four times larger amount of released silver ions, two times larger zone of inhibition, and one additional order of magnitude of reduction in numbers of CFU in an ex vivo mouse infection model.
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Colonic gene expression patterns of mucin muc2 knockout mice reveal various phases in colitis development
Peng Lu,Nanda Burger-van Paassen,Maria van der Sluis,Janneke Witte-Bouma,Jean-Pierre Kerckaert,Johannes B. van Goudoever,Isabelle Van Seuningen,Ingrid B. Renes +7 more
TL;DR: Together, these data demonstrate that there are distinct phases in colitis development in 2–4‐week‐old Muc2−/− mice and upregulation of genes stimulating cell growth correlated with increased crypt length and increased epithelial proliferation in 4‐week-old MUC2− /− mice.
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High beta-palmitate fat controls the intestinal inflammatory response and limits intestinal damage in mucin Muc2 deficient mice.
Peng Lu,Peng Lu,Fabiana Bar-Yoseph,Liora Levi,Yael Lifshitz,Janneke Witte-Bouma,Adrianus C. J. M. de Bruijn,Anita M. Korteland-van Male,Johannes B. van Goudoever,Johannes B. van Goudoever,Ingrid B. Renes,Ingrid B. Renes +11 more
TL;DR: This study shows for the first time that HBPF diet limits the intestinal mucosal damage and controls the inflammatory response in Muc2−/− mice by inducing an immunosuppressive Treg cell response.
Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification.
Callie Knuth,E. Andrés Sastre,Niamh Fahy,Janneke Witte-Bouma,Yanto Ridwan,E M Strabbing,M J Koudstaal,J van de Peppel,Eppo B. Wolvius,Roberto Narcisi,Eric Farrell +10 more
TL;DR: The present study investigated the importance of COLX by shRNA-mediated gene silencing in primary MSCs and found that a significant knock-down ofCOLX disrupted the production of extracellular matrix key components and the secretion profile of chondrogenically differentiated MSCS.
Endoplasmic Reticulum Stress, Unfolded Protein Response and Altered T Cell Differentiation in Necrotizing Enterocolitis
Peng Lu,Peng Lu,Marie-Chantal Struijs,Jiaping Mei,Janneke Witte-Bouma,Anita M. Korteland-van Male,Adrianus C. J. M. de Bruijn,Johannes B. van Goudoever,Johannes B. van Goudoever,Ingrid B. Renes,Ingrid B. Renes +10 more
TL;DR: XBP1 splicing, ER stress and the UPR in NEC are associated with increased IL6 and IL8 expression levels, altered T cell differentiation and severe epithelial injury.