Janne Hukkanen
Oulu University Hospital
72 Papers
215 Citations
Janne Hukkanen is an academic researcher from Oulu University Hospital. The author has contributed to research in topics: Medicine & CYP2A6. The author has an hindex of 28, co-authored 56 publications. Previous affiliations of Janne Hukkanen include University of Oulu & University of California, San Francisco.
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Papers
Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line.
Janne Hukkanen,Arja Lassila,Katja Päivärinta,Susanna Valanne,Sari Sarpo,Jukka Hakkola,Olavi Pelkonen,Hannu Raunio +7 more
TL;DR: CYP1A1 and CYP1B1 are differentially regulated in human pulmonary epithelial cells and give the first indication of the induction of CYP3A5 by glucocorticoids in human lung cells.
Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.
Janne Hukkanen,Jukka Hakkola,Sisko Anttila,Ritva Piipari,Antti Karjalainen,Olavi Pelkonen,Hannu Raunio +6 more
TL;DR: An overall picture of the expression of CYP genes in the xenobiotic‐metabolizing families CYP1, CYP2, and CYP3 in BAMs, peripheral blood lymphocytes, and whole‐lung tissue is given and will aid in directing future studies on the respective protein products.
The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity.
Janne Hukkanen,Johanna Puurunen,Johanna Puurunen,Tuulia Hyötyläinen,Markku J. Savolainen,Aimo Ruokonen,Aimo Ruokonen,Laure Morin-Papunen,Laure Morin-Papunen,Matej Orešič,Terhi Piltonen,Terhi Piltonen,Juha S. Tapanainen +12 more
TL;DR: The results establish atorvastatin as an inhibitor of CYP3A4 activity, including the conditions with altered cholesterol concentrations, and 4βHC : C is a useful index of CYF3A 4 activity.
Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells.
Jukka Hakkola,Markku Pasanen,Olavi Pelkonen,Janne Hukkanen,Sari Evisalmi,Sisko Anttila,Anders Rane,Marjatta Mantyla,Raija Purkunen,Seppo Saarikoski,Merike Tooming,Hannu Raunio +11 more
TL;DR: Evidence is provided that in addition to the Ah receptor complex, other cell-specific factors modulate the response of CYP1B1 and CyP1A1 to Ah receptor ligands.
Five-year follow-up of a randomized weight loss trial on a digital health behaviour change support system.
Eero Turkkila,Taru Pekkala,Heta Merikallio,Marko Merikukka,Laura Heikkilä,Janne Hukkanen,Harri Oinas-Kukkonen,Tuire Salonurmi,Anna-Maria Teeriniemi,Terhi Jokelainen,Markku J Savolainen +10 more
TL;DR: This 5-year follow-up study of a digital health behaviour change support system found that users maintained weight loss and reduced blood pressure medication needs, with significant weight difference favouring the system over non-users at 5 years.