Janine Büttner
Charité
19 Papers
112 Citations
Janine Büttner is an academic researcher from Charité. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 12, co-authored 17 publications.
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Papers
Hereditary Apolipoprotein AI-Associated Amyloidosis in Surgical Pathology Specimens: Identification of Three Novel Mutations in the APOA1 Gene
Magdalena Eriksson,Stefan Schönland,Saniye Yumlu,Ute Hegenbart,Hanna von Hutten,Zarina Gioeva,Peter Lohse,Janine Büttner,Hartmut Schmidt,Christoph Röcken +9 more
TL;DR: Apolipoprotein AI-derived (AApoAI) amyloidosis may present either as a non-hereditary form with wild-type protein deposits in atherosclerotic plaques or as a hereditary form due to germline mutations in the APOA1 gene as mentioned in this paper.
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Increased small intestinal permeability in ulcerative colitis: Rather genetic than environmental and a risk factor for extensive disease?
Carsten Büning,Nora Geissler,Matthias Prager,Andreas Sturm,Daniel C. Baumgart,Janine Büttner,Sabine Buhner,Verena Haas,Herbert Lochs +8 more
TL;DR: An increased intestinal but not colonic permeability was found in UC patients in clinical remission that could mark a new risk factor for extensive disease location and similar findings in healthy relatives but not spouses suggest that this barrier defect is genetically determined.
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Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis.
Carsten Büning,H. Schmidt,T Molnár,Dirk J. de Jong,Thomas Fiedler,Sabine Buhner,Andreas Sturm,Daniel C. Baumgart,Ferenc Nagy,János Lonovics,Joost P.H. Drenth,Olfert Landt,Renate Nickel,Janine Büttner,Herbert Lochs,Heiko Witt +15 more
TL;DR: A non‐synonymous single nucleotide polymorphism located in the IL23R gene is a protective marker for inflammatory bowel disease and should be investigated for use in clinical practice.
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Mutational analysis of ATP7B gene in Egyptian children with Wilson disease: 12 novel mutations.
Tawhida Y. Abdel-Ghaffar,Solaf M. Elsayed,Ezzat Elsobky,Bettina Bochow,Janine Büttner,Hartmut H.-J. Schmidt +5 more
TL;DR: Despite mutation heterogeneity in Egyptian children, genotype-phenotype correlation analysis seems to be promising in this population, as many patients carry homozygous mutations, a situation that mandates a larger-scale population screening to identify the carrier rate in this community.
Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease.
Thomas Fiedler,Carsten Büning,W Reuter,G. Pitre,Enno Gentz,Hartmut H.-J. Schmidt,Janine Büttner,Johann Ockenga,T Gerloff,C Meisel,Herbert Lochs,Ivar Roots,Karla Köpke,Andreas Johne +13 more
TL;DR: While overall genotype distribution did not differ, combined MDR1 genotypes derived from positions 2677 and 3435 are possibly associated with young age onset of UC and severe course of disease in this patient group.
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