Ja’Nia McPhatter
University of Pittsburgh
3 Papers
Ja’Nia McPhatter is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Complement system. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of Ja’Nia McPhatter include Washington University in St. Louis.
Chat about Author
Papers
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Lina Ma,Sanjaya Kumar Sahu,Marlene Cano,Vasanthan Kuppuswamy,Jamal Bajwa,Jamal Bajwa,Ja’Nia McPhatter,Ja’Nia McPhatter,Alexander B Pine,Matthew L Meizlish,George Goshua,C. Hong Chang,Hanming Zhang,Christina Price,Parveen Bahel,Henry M. Rinder,Tingting Lei,Aaron Day,Daniel Reynolds,Xiaobo Wu,Rebecca E Schriefer,Adriana M Rauseo,Charles W. Goss,Jane A. O’Halloran,Rachel M. Presti,Alfred H.J. Kim,Andrew E. Gelman,Charles S. Dela Cruz,Alfred Ian Lee,Philip A. Mudd,Hyung J. Chun,John P. Atkinson,Hrishikesh S. Kulkarni +32 more
TL;DR: In this article, the authors investigated complement activation in the plasma from patients with COVID-19 prospectively enrolled at two tertiary care centers: Washington University School of Medicine (n=134) and Yale Medical Center(n=49) and compared their patients to two non-COVID cohorts: (a) patients hospitalized with influenza and (b) patients admitted to the ICU with acute respiratory failure requiring invasive mechanical ventilation (IMV, n=22).
193
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
Lina Ma,Sanjaya Kumar Sahu,Marlene Cano,Vasanthan Kuppuswamy,Jamal Bajwa,Jamal Bajwa,Ja’Nia McPhatter,Ja’Nia McPhatter,Alexander B Pine,Matthew L Meizlish,George Goshua,C-Hong Chang,Hanming Zhang,Christina Price,Parveen Bahel,Henry M. Rinder,Tingting Lei,Aaron Day,Daniel Reynolds,Xiaobo Wu,Rebecca E Schriefer,Adriana M Rauseo,Charles W. Goss,Jane A. O’Halloran,Rachel M. Presti,Alfred H.J. Kim,Andrew E. Gelman,Charles S. Dela Cruz,Alfred Ian Lee,Phillip Mudd,Hyung J. Chun,John P. Atkinson,Hrishikesh S. Kulkarni +32 more
TL;DR: Increased complement activation in COVID-19 compared to influenza and non-COVID respiratory failure is reported, and alternative pathway activation is demonstrated as a key marker of multiorgan failure and death.
Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury
Ayşe Naz Ozantürk,Sanjaya Kumar Sahu,Devesha H. Kulkarni,Lina Ma,Ruteja A. Barve,Ja’Nia McPhatter,L. Garnica,L. Dannull,J. Kunen,Xiaobo Wu,Steven L. Brody,John P. Atkinson,Hrishikesh S. Kulkarni +12 more
TL;DR: In this paper , the authors analyzed the effects of local versus peripheral sources of complement component C3 expression in a model of bacterial pneumonia and found that locally-derived C3-Factor B pathway protects the lung mucosal barrier.
28