Janet T. Powell
Imperial College London
316 Papers
2.7K Citations
Janet T. Powell is an academic researcher from Imperial College London. The author has contributed to research in topics: Abdominal aortic aneurysm & Medicine. The author has an hindex of 74, co-authored 309 publications. Previous affiliations of Janet T. Powell include Charing Cross Hospital & University Hospitals Coventry and Warwickshire NHS Trust.
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Papers
Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue.
TL;DR: A 40% reduction in MMP-9 levels in the AAA wall in patients randomised to simvastatin provides a possible molecular mechanism to explain the reportedly beneficial effects of statins to slow AAA growth.
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High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease
S. T. R. Macsweeney,M. O'Meara,Christine Alexander,M. K. O’Malley,Janet T. Powell,Roger M. Greenhalgh +5 more
TL;DR: Patients with arterial disease have a high risk of abdominal aortic aneurysm and routine ultrasonographic screening should be considered, and physical examination was an inadequate method of screening.
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The UK endovascular aneurysm repair (EVAR) randomised controlled trials: Long-term follow-up and cost-effectiveness analysis
Rajesh Patel,Janet T. Powell,Michael J. Sweeting,David Epstein,David Epstein,Jessica K. Barrett,Roger M. Greenhalgh +6 more
TL;DR: The long-term efficacy of EVAR against OR in patients deemed fit and suitable for both procedures (EVAR trial 1; EVAR-1); and against no intervention in patients unfit for OR (evAR-2) is assessed to appraise the long- term significance of type II endoleak and define criteria for intervention.
A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm
Gregory T. Jones,Matthew J. Bown,Matthew J. Bown,Solveig Gretarsdottir,Simon P. R. Romaine,Anna Helgadottir,Grace Yu,Gerard Tromp,Paul Norman,Cao Jin,Annette F. Baas,Jan D. Blankensteijn,Iftikhar J. Kullo,L. Victoria Phillips,Michael J.A. Williams,Ruth Topless,Tony R. Merriman,Thodor M. Vasudevan,David R. Lewis,Ross D. Blair,Andrew Hill,Robert D. Sayers,Robert D. Sayers,Janet T. Powell,Panagiotis Deloukas,Gudmar Thorleifsson,Stefan E Matthiasson,Unnur Thorsteinsdottir,Jonathan Golledge,Robert A. S. Ariëns,Anne Johnson,S Sohrabi,D. Julian A. Scott,David J. Carey,Robert Erdman,James R. Elmore,Helena Kuivaniemi,Nilesh J. Samani,Nilesh J. Samani,Kari Stefansson,Andre M. van Rij +40 more
TL;DR: A genetic marker associated with cardiovascular risk factors, and in particular concurrent vascular disease, appeared to independently contribute to susceptibility for AAA, given the potential genetic overlap between risk factor and disease phenotypes.
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Multifactorial inheritance of abdominal aortic aneurysm.
TL;DR: Both the younger age of presentation and the concentration of women amongst those with a positive family history argue for multifactorial inheritance of abdominal aortic aneurysm, with the genetic component calculated as approximately 70%.
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