Janet Jackman
Genentech
40 Papers
215 Citations
Janet Jackman is an academic researcher from Genentech. The author has contributed to research in topics: Asthma & Psoriasis. The author has an hindex of 17, co-authored 37 publications. Previous affiliations of Janet Jackman include Hoffmann-La Roche.
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Papers
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
David F. Choy,Kevin M. Hart,Lee A. Borthwick,Aarti Shikotra,Deepti R. Nagarkar,Salman Siddiqui,Guiquan Jia,Chandra M. Ohri,Emma Doran,Emma Doran,Kevin M. Vannella,Claire A. Butler,Beverley Hargadon,Joshua Sciurba,Richard L. Gieseck,Robert W. Thompson,Sandra White,Alexander R. Abbas,Janet Jackman,Lawren C. Wu,Jackson G. Egen,Liam G Heaney,Thirumalai R. Ramalingam,Joseph R. Arron,Thomas A. Wynn,Peter Bradding +25 more
TL;DR: It is demonstrated that asthma can be divided into three immunological clusters: TH2-high, TH17- high, and TH2/17- low, and the data suggest that combination therapies targeting both pathways may better treat asthmatic individuals.
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Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma
Aarti Shikotra,David F. Choy,Chandra M. Ohri,Emma Doran,Claire A. Butler,Beverley Hargadon,M Shelley,Alexander R. Abbas,Cary D. Austin,Janet Jackman,Lawren C. Wu,Liam G Heaney,Joseph R. Arron,Peter Bradding +13 more
TL;DR: TSLP expression is increased in a subset of patients with severe asthma in spite of high-dose inhaled or oral corticosteroid therapy, and targeting TSLP might only be efficacious in the subset of asthma characterized by increased T SLP expression and T(H)2 inflammation.
323
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
Henry R. Maun,Janet Jackman,David F. Choy,Kelly M. Loyet,Tracy Staton,Guiquan Jia,Amy Dressen,Jason A. Hackney,Meire Bremer,Benjamin T. Walters,Rajesh Vij,Xiaocheng Chen,Neil N. Trivedi,Neil N. Trivedi,Ashley Morando,Michael T. Lipari,Yvonne Franke,Xiumin Wu,Juan Zhang,John Liu,Ping Wu,Diana Chang,Luz D. Orozco,Erin H. Christensen,Manda Wong,Racquel Corpuz,Julie Q. Hang,Jeff Lutman,Siddharth Sukumaran,Yan Wu,Savita Ubhayakar,Xiaorong Liang,Lawrence B. Schwartz,Magda Babina,Prescott G. Woodruff,John V. Fahy,Rahul Ahuja,Rahul Ahuja,George H. Caughey,George H. Caughey,Aija Kusi,Mark S. Dennis,Charles Eigenbrot,Daniel Kirchhofer,Cary D. Austin,Lawren C. Wu,James T. Koerber,Wyne P. Lee,Brian L. Yaspan,Kathila R. Alatsis,Joseph R. Arron,Robert A. Lazarus,Tangsheng Yi +52 more
TL;DR: A noncompetitive inhibitory antibody against human β-tryptase is generated that potently blocks tryptase enzymatic activity in a humanized mouse model, reducing IgE-mediated systemic anaphylaxis, and inhibits airwaytryptase in Ascaris-sensitized cynomolgus monkeys with favorable pharmacokinetics.
94
Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines *
Christoph Spiess,Jack Bevers,Janet Jackman,Nan Chiang,Gerald R. Nakamura,Michael Dillon,Hongfang Liu,Patricia Molina,J. Michael Elliott,Whitney Shatz,Justin Scheer,Glen Giese,Josefine Persson,Yin Zhang,Mark S. Dennis,James Giulianotti,Prateek Gupta,Dorothea Reilly,Enzo Palma,Jianyong Wang,Eric Stefanich,Heleen Scheerens,Germaine Fuh,Lawren C. Wu +23 more
TL;DR: It is shown that IgG4 bispecific antibodies can be generated in large quantities with equivalent efficiency and quality and have comparable pharmacokinetic properties and lung partitioning, compared with the IgG1 isotype.
68
LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies.
Bernd Wranik,Erin L. Christensen,Gabriele Schaefer,Janet Jackman,Andrew C. Vendel,Dan L. Eaton +5 more
TL;DR: The LUZ-Y platform is presented, a novel platform for the mammalian cell production of bispecific antibodies that differ from their parental mAbs by only a single point mutation per heavy chain that is sufficient to drive the heterodimeric assembly of antibody heavy chains and can be readily removed post-purification.
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