Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals.

Cancer chemoprevention with dietary phytochemicals

http://www.columbia.edu/cu/biology/dept/seminarPDFfiles/CELL.CK1.pdf

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Caught up in a Wnt storm: Wnt signaling in cancer.

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.

http://www.jbc.org/content/272/40/24735.full.pdf

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin *

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Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin *