Jane Newcombe
University of Surrey
26 Papers
365 Citations
Jane Newcombe is an academic researcher from University of Surrey. The author has contributed to research in topics: Neisseria meningitidis & Gene. The author has an hindex of 13, co-authored 23 publications. Previous affiliations of Jane Newcombe include Stockholm University.
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Papers
PCR of peripheral blood for diagnosis of meningococcal disease.
TL;DR: It is demonstrated that a substantial number of cases of meningococcal disease are not confirmed by conventional techniques and remain undiagnosed, and it is likely that the authors are in a prevaccination era for meningitis.
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Identification of proteins from tuberculin purified protein derivative (PPD) by LC-MS/MS.
TL;DR: A proteomics-based characterization of PPD from several different sources by LC-MS/MS, which combines the solute separation power of HPLC, with the detection power of a mass spectrometer, is described.
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Generation and characterization of a PhoP homologue mutant of Neisseria meningitidis
C. R. Johnson,Jane Newcombe,S. Thorne,H. A. Borde,Lesley-Jane Eales-Reynolds,Andrew Gorringe,Simon G. P. Funnell,Johnjoe McFadden +7 more
TL;DR: It is suggested that the meningococcal PhoP/PhoQ system may similarly be involved in the regulation of virulence genes in response to environmental stimuli in theMeningococcus.
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The Acute-Phase Reactant C-Reactive Protein Binds to Phosphorylcholine-Expressing Neisseria meningitidis and Increases Uptake by Human Phagocytes
TL;DR: It is shown that CRP can bind to piliated meningococci in a classical calcium-dependent manner and appears to act as an opsonin for N. meningitidis, as CRP-opsonized bacteria showed increased uptake by human macrophages and neutrophils.
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Infection with an Avirulent phoP Mutant of Neisseria meningitidis Confers Broad Cross-Reactive Immunity
Jane Newcombe,Lesley-Jane Eales-Reynolds,L. Wootton,Andrew Gorringe,Simon G. P. Funnell,Stephen Taylor,Johnjoe McFadden +6 more
TL;DR: It is shown that a phoP mutant of the meningococcus is avirulent in a mouse model of infection and is thus a candidate live, attenuated vaccine strain and may also be used to identify cross-reactive protective antigens in the menedococcus.
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