Jane Grogan
5 Papers
Jane Grogan is an academic researcher. The author has contributed to research in topics: Gene & Biology. The author has co-authored 2 publications.
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Papers
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
Juan A. Perez-Bermejo,Oghene Efagene,William M Matern,Jeffrey K. Holden,Shaheen Kabir,Glen M. Chew,Gaia Andreoletti,Eniola Catton,Craig L. Ennis,Trevor L. Gerstenberg,Kaisle A. Hill,Kristina Krassovsky,Cassandra D. Lalisan,Daniel Lord,B. J. Quejarro,Jade Sales-Lee,Meet Shah,Brian J Silva,Jason Skowronski,Yuri G. Strukov,Joshua Thomas,Michael Veraz,Twaritha Vijay,Kirby A. Wallace,Jane Grogan,Beeke Wienert,Premanjali Lahiri,Sebastian Treusch,Daniel P. Dever,Vanessa B. Soros,James R. Partridge,Kristen L Seim +31 more
TL;DR: Researchers develop a functional screening platform to identify protein-based enhancers of Homology Directed Repair (HDR) in human hematopoietic stem and progenitor cells, discovering optimized variants that increase HDR efficiency and reduce off-target editing.
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Development of a β-Globin Gene Replacement Strategy As a β-Thalassemia Therapy
Kirby Wallace,Beeke Wienert,Christopher Bandoro,James Partridge,Craig L. Ennis,Casey D. Lalisan,Kristina Krassovsky,Gaia Andreoletti,Rajiv P. Sharma,Aishwarya Churi,William M. Matern,Sebastian Treusch,Jane Grogan,Daniel P. Dever +13 more
TL;DR: In this paper , a gene-editing platform using homology-directed repair (HDR) that could replace the entire HBB gene in situ and under the control of normal regulatory elements would be an ideal strategy.
A differentiated β-globin gene replacement strategy uses heterologous introns to restore physiological expression
Kirby A. Wallace,Trevor L. Gerstenberg,Craig L. Ennis,Juan A. Perez-Bermejo,James R. Partridge,Christopher Bandoro,W. Matern,Gaia Andreoletti,Kristina Krassovsky,Shaheen Kabir,Cassandra D. Lalisan,Aishwarya Churi,Glen M. Chew,Lana Corbo,Jon E. Vincelette,Timothy D. Klasson,Brian J Silva,Yuri G. Strukov,B. J. Quejarro,Kaisle A. Hill,Sebastian Treusch,Jane Grogan,Daniel P. Dever,Matthew H. Porteus,Beeke Wienert +24 more
Single-Cell RNA Sequencing of Sickle Cell Reticulocytes to Identify Beta-Globin Genotypes and Associated Gene Expression Differences
Sebastian Treusch,Twaritha Vijay,William M. Matern,Kristina Krassovsky,Vincent Siu,Ian Perrone,Glen M. Chew,Jane Grogan,Alana G. Lerner +8 more
TL;DR: In this article , a single-cell RNA sequencing (scRNAseq) method was developed to enable enumeration of potential gene-editing outcomes in peripheral reticulocytes.
Functional Screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
Juan A. Perez-Bermejo,Oghene Efagene,William M. Matern,Jeffrey K. Holden,Shaheen Kabir,Glen M. Chew,Gaia Andreoletti,Eniola Catton,Craig L. Ennis,Angelica Garcia,Trevor L. Gerstenberg,Kaisle A. Hill,Kristina Krassovsky,Cassandra D. Lalisan,Daniel Lord,B. J. Quejarro,Jade Sales-Lee,Brian J. Silva,Jason Skowronski,Yuri G. Strukov,Joshua Thomas,Michael Veraz,Twaritha Vijay,Kirby A. Wallace,Yue Yuan,Jane Grogan,Beeke Wienert,Premanjali Lahiri,Sebastian Treusch,Daniel P. Dever,Vanessa B. Soros,James R. Partridge,Kristen L. Seim +32 more
TL;DR: The development of a functional, pooled screening platform utilizing an HDR-based readout to identify protein-based reagents that improve HDR outcomes in human hematopoietic stem and progenitor cells (HSPCs), a clinically relevant cell type for gene therapy.