Jane E. Schupp
Case Western Reserve University
28 Papers
465 Citations
Jane E. Schupp is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Cell cycle & DNA mismatch repair. The author has an hindex of 15, co-authored 28 publications. Previous affiliations of Jane E. Schupp include University Hospitals of Cleveland & West Virginia University.
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Papers
A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition.
Sanjeev Kumar,Sun Hee Park,Benjamin Cieply,Jane E. Schupp,Elizabeth J. Killiam,Fan Zhang,David L. Rimm,Steven M. Frisch +7 more
TL;DR: A pathway through which EMT confers anoikis resistance by downregulating E-cadherin and TBX2 interacts with NRAGE, repressing the tumor suppressor gene p14ARF, and represents a novel pathway for the regulation of anoIKis by EMT and E- cadher in.
133
•Journal Article
Selection for G156A O6-Methylguanine DNA Methyltransferase Gene-transduced Hematopoietic Progenitors and Protection from Lethality in Mice Treated with O6-Benzylguanine and 1,3-Bis(2-chloroethyl)-1-nitrosourea
TL;DR: In this paper, a retroviral gene therapy approach was developed to protect early hematopoietic progenitors from 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a stem cell toxin, and O 6-benzylguanine (BG), an inhibitor of a key BCNU resistance protein, O 6alkylguansine DNA alkyltransferase (AGT).
117
•Journal Article
Loss of DNA Mismatch Repair Imparts Defective cdc2 Signaling and G2 Arrest Responses without Altering Survival after Ionizing Radiation
Tao Yan,Jane E. Schupp,Hwa-Shin Hwang,Mark W. Wagner,Suzanne E. Berry,S. Strickfaden,Martina L. Veigl,W. D. Sedwick,David A. Boothman,Timothy J. Kinsella +9 more
TL;DR: Although MMR status does not significantly affect the survival of cells after high-dose-rate IR, it seems to regulate the G(2)-M checkpoint and might affect overall mutation rates.
83
•Journal Article
Inhibition of Base Excision Repair Potentiates Iododeoxyuridine-induced Cytotoxicity and Radiosensitization
Pietro Taverna,Hwa Shin Hwang,Jane E. Schupp,Tomas Radivoyevitch,Nancy Nguyen Session,Guru Reddy,David A. Zarling,Timothy J. Kinsella +7 more
TL;DR: A genetic or biochemical impairment of BER results in increased IdUrd-induced cytotoxicity and radiosensitization in mammalian cells.
81
DNA Mismatch Repair Initiates 6-Thioguanine–Induced Autophagy through p53 Activation in Human Tumor Cells
TL;DR: It is found that MMR is required for mediating autophagy in response to 6-TG treatment in these human tumor cells and p53 plays an essential role in signaling from MMR to the autophagic pathway.
79