25 Papers
186 Citations
Jan Snášel is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Integrase & RNase P. The author has an hindex of 11, co-authored 21 publications.
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Papers
Cleavage of vimentin by different retroviral proteases.
Jan Snášel,Robert L. Shoeman,Magda Horejsi,Olga Hrušková−Heidingsfeldová,Juraj Sedlacek,Tomáš Ruml,Iva Pichová +6 more
TL;DR: In vitro cleavage of mouse vimentin by proteases of human immunodeficiency virus type 1 and type 2, bovine leukemia virus (BLV), Mason-Pfizer monkey virus (M-PMV), myeloblastosis-associated virus (MAV), and two active-site mutants of MAV PR is analyzed.
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CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases
Pavla Spácilová,Petr Nauš,Radek Pohl,Ivan Votruba,Jan Snášel,Helena Zábranská,Iva Pichová,Ria Ameral,Gabriel Birkus,Tomas Cihlar,Michal Hocek +10 more
TL;DR: Several pronucleotides were found which strongly inhibit human adenosine kinase but only weakly inhibit the MTB adenosines kinase.
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Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Dominik Rejman,Jan Snášel,Radek Liboska,Zdeněk Točík,Ondřej Pačes,Šárka Králíková,Markéta Rinnová,Pavol Kois,Ivan Rosenberg +8 more
TL;DR: Several types of isopolar modified oligothymidylates and oligoadenylates with the phosphonate -O-P-CH 2-O- internucleotide linkage were prepared and subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
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4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics.
Radek Liboska,Jan Snášel,Ivan Barvík,Miloš Buděšínský,Radek Pohl,Zdeněk Točík,Ondřej Páv,Dominik Rejman,Pavel Novák,Ivan Rosenberg +9 more
TL;DR: The favourable hybridisation properties of the 4'-alkoxyoligothymidylates indicated that 4-alkoxy modified nucleotides are promising compounds for the assembly of chimeric oligonucleotides with tunable properties.
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6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents
Pavla Perlíková,Petr Konečný,Petr Nauš,Jan Snášel,Ivan Votruba,Petr Džubák,Iva Pichová,Marian Hajduch,Michal Hocek,Michal Hocek +9 more
TL;DR: 6-Methyl-7-deazapurine ribonucleoside was found to be a potent antimycobacterial agent and several new derivatives bearing bulky substituents at position 6 were non-cytotoxic but selectively inhibited MTB ADK.