Jan Sinclair
Boston Children's Hospital
20 Papers
107 Citations
Jan Sinclair is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Food allergy & Population. The author has an hindex of 7, co-authored 19 publications.
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Papers
Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
Zinan Zhang,Zinan Zhang,Zinan Zhang,Florian Gothe,Florian Gothe,Perrine Pennamen,John R. James,David MacDonald,Carlos P. Mata,Carlos P. Mata,Yorgo Modis,Yorgo Modis,Anas M. Alazami,Meghan Acres,Wolfram Haller,Claire Bowen,Rainer Doffinger,Jan Sinclair,Yu Zhang,Helen F. Matthews,Sophie Naudion,Fanny Pelluard,Huda Alajlan,Yasuhiro Yamazaki,Luigi D. Notarangelo,James Thaventhiran,Karin R. Engelhardt,Hamoud Al-Mousa,Sophie Hambleton,Sophie Hambleton,Caroline Rooryck,Kenneth G. C. Smith,Michael J. Lenardo +32 more
TL;DR: The hypomorphic gene mutations reveal variable IL-2Rβ expression and function between different lymphocyte subsets as a means of selectively modulating immune responses.
Monogenic Early-Onset Lymphoproliferation and Autoimmunity: The Natural History of STAT3 GOF Syndrome.
Jennifer W. Leiding,Tiphanie P. Vogel,Valentine G.J. Santarlas,Rahul Mhaskar,Madison R. Smith,Alexandre F. Carisey,Alexander Vargas-Hernández,Manuel Silva-Carmona,Maximilian Heeg,Anne Rensing-Ehl,Bénédicte Neven,Jérôme Hadjadj,Sophie Hambleton,Timothy Ronan Leahy,Martin van Hagen,Charlotte Cunningham-Rundles,Cullen M. Dutmer,Svetlana O. Sharapova,Mervi Taskinen,Ignatius Chua,Rosie Hague,Christian Klemann,Larysa Kostyuchenko,Tomohiro Morio,Akaluck Thatayatikom,Ahmet Ozen,Anna Scherbina,Cindy S. Bauer,Sarah E. Flanagan,Eleonora Gambineri,Lisa Giovannini-Chami,Jennifer Heimall,Kathleen E. Sullivan,Eric J. Allenspach,Neil Romberg,Sean Deane,Benjamin T Prince,Melissa J. Rose,John Bohnsack,Talal Mousallem,Rohith Jesudas,Maria Marluce dos Santos Vilela,Michael O'Sullivan,Jana Pachlopnik Schmid,Stepanka Pruhova,Matthew Rees,Helen C. Su,Sami L. Bahna,Safa Baris,Lisa M. Bartnikas,Amy Chang Berger,Tracy A Briggs,S. Brothers,Vanessa Bundy,Alice Y. Chan,Shanmuganathan Chandrakasan,Mette Christiansen,Theresa Cole,Matthew C. Cook,Mukesh Desai,Ute Fischer,David A. Fulcher,Silvanna Gallo,A. Gauthier,Andrew R. Gennery,José G. Marques,Frédéric Gottrand,Bodo Grimbacher,Eyal Grunebaum,Emma Haapaniemi,Sari Hämäläinen,Kaarina Heiskanen,Tarja Heiskanen-Kosma,Hal M. Hoffman,Luis Ignacio Gonzalez-Granado,A. L. Guerreiro,Leena Kainulainen,Ashish R Kumar,Monica G. Lawrence,Carina Levin,Timi Martelius,Olaf Neth,Peter Olbrich,Alejandro Palma,Niraj C. Patel,Tamara C Pozos,Kahn Preece,Saul Oswaldo Lugo Reyes,M.A. Russell,Yael Dinur Schejter,Christine M. Seroogy,Jan Sinclair,Effie Skevofilax,Dan Suan,Daniel Suegeorgz,Paul Szabolcs,Helena Fleck Velasco,Klaus Warnatz,Kelly Walkovich,Austen Worth,Mikko Seppänen,Troy R. Torgerson,Georgios Sogkas,Stephan Ehl,Stuart G. Tangye,Megan A. Cooper,Joshua D. Miller,Lisa R Forbes Satter,Svetlana Aleshkevich,Luis M. Allende,T. Prescott Atkinson,Faranaz Atschekzei,Sezin Aydemir,Utku Aygunes,Vincent Barlogis,Ulrich Baumann,John Belko,Liliana Bezrodnik,Ariane Biebl,Lori Broderick,Nancy Bunin,María Soledad Caldirola,Martin Castelle,Fatih Celmeli,Louis-Marie Charbonnier,Talal A. Chatila,Deepak Chellapandian,Haluk Cokugras,Niall Conlon,Fionnuala Cox,Etienne Crickx,Buket Dalgic,Virgil A. S. H. Dalm,Silvia Danielian,Nerea Domínguez-Pinilla,Tal Dujovny,Mikael Ebbo,Ahmet Eken,Brittany Esty,Alexandre Fabre,Alain Fischer,Mark C. Hannibal,Laura A. Huppert,Marc D. Ikeda,Stephen Jolles,Kent W. Jolly,Neil Jones,Musa Kakakukcu,Maria Kanariou,Elif Karakoc-Aydiner,Theoni Karamantziani,Charikleia Kelaidi,M. J. Keogan,Ayşenur Paç Kısaarslan,Ayca Kiykim,Adam Klocperk,Kosmas Kotsonis,Natalia B. Kuzmenko,Sylvie Leroy,Harry Lesmana,D. Lianou,Hilary Longhurst,Myriam Ricarda Lorenz,Patrick Maffucci,Ania Manson,Sarah Marchal,Marion Malphettes,L. F. Marega,Andrea A. Mauracher,Kornvalee Meesilpavikai,Holly K. Miller,Joy Mombourquette,Noel G. Morgan,Anna Mukhina,Aladjidi Nathalie,Brigitte Nelken,David Nolan,Anna-Carin Norlin,Matías Oleastro,Alper Ozcan,Marlène Pasquet,José R.M. Pegler,Capucine Picard,Sophia Polychronopoulou,Pierre Quartier,Jan Ramakers,Katrina L. Randall,V. Koneti Rao,Allison Sarah Remiker,Géraldine Resin,Peter Richmond,Frédéric Rieux-Laucat,Yulia Rodina,Pierre-Simon Rohrlich,John Sachs,Inga S. Sakovich,Christopher Santarlas,Sinan Sari,Gregory S. Sawicki,Uwe Dr. Schauer,Selma Cecilia Scheffler Mendoza,Oksana Schvetz,Reinhold E. Schmidt,Klaus Schwarz,Anna Sediva,Kyle James Sinclair,Mary Slatter,John W. Sleasman,Katerina Stergiou,Narissara Suratannon,Kayo Tanita,Grace Thompson,Stephen Travis,Timothy David Trojan,Maria Tsinti,Ekrem Unal,Luciano Urdinez,Felisa Vázquez-Gómez,Maria del Carmen Garcia Villa,Michael Weinrich,Mitchell J. Weiss,B. Wright,Ebru Yilmaz,Radana Zachova,Juan F. Quesada +224 more
TL;DR: In this paper , the authors defined the scope, natural history, treatment, and overall survival of a large global cohort of patients with pathogenic STAT3 gain-of-function (GOF) variants.
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Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients
Roxane Labrosse,Roxane Labrosse,Sara Barmettler,Beata Derfalvi,Annaliesse Blincoe,Guilhem Cros,Jonathan Lacombe-Barrios,Julie Barsalou,Nancy Yang,Nora Alrumayyan,Jan Sinclair,Mei-Sing Ong,Carlos A. Camargo,Jolan E. Walter,Jolan E. Walter,Elie Haddad +15 more
TL;DR: In this article, the prevalence, risk factors, and clinical significance of hypogammaglobulinemia following rituximab therapy in children were determined, with an increase in prevalence of hypo-IgG (28.7%-42.6%, P =.009).
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An outbreak of meningococcal disease in Auckland, New Zealand.
TL;DR: A large epidemic of disease caused by Group A sulfonamide-resistant Neisseria meningitidis has been occurring in Auckland, New Zealand, from June, 1985, and peaking in October, 1985 (spring), and June, 1986 (winter).
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•Journal Article
The changing epidemiology of food allergy--implications for New Zealand.
Christine Crooks,Rohan Ameratunga,Greg Simmons,Penny Jorgensen,Clare R Wall,Maia Brewerton,Jan Sinclair,Richard Steele,Shanthi Ameratunga +8 more
TL;DR: The epidemiological data on FA is summarized, the implications for New Zealand are discussed, and published estimates of incidence and prevalence are discussed.