Jan Lassus
University of Helsinki
8 Papers
138 Citations
Jan Lassus is an academic researcher from University of Helsinki. The author has contributed to research in topics: Cathepsin K & Cathepsin. The author has an hindex of 7, co-authored 8 publications.
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Papers
Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis.
Yrjö T. Konttinen,Jami Mandelin,Tian-Fang Li,Jari Salo,Jan Lassus,Mikko Liljeström,Mika Hukkanen,Michiaki Takagi,Ismo Virtanen,Seppo Santavirta +9 more
TL;DR: The findings suggest that cathepsin K, rather than neutral matrix metalloproteinases, degrades the superficial gliding surfaces of the articular hyaline cartilage in OA.
196
Acid Attack and Cathepsin K in Bone Resorption Around Total Hip Replacement Prosthesis
Yrjö T. Konttinen,Michiaki Takagi,Jami Mandelin,Jan Lassus,Jari Salo,Mari Ainola,Tian-Fang Li,Ismo Virtanen,Mikko Liljeström,Hideaki Sakai,Yasuhiro Kobayashi,Timo Sorsa,Reijo Lappalainen,Reijo Lappalainen,Anne Demulder,Seppo Santavirta +15 more
TL;DR: Observations suggest the presence of an acid‐ and cathepsin K‐driven pathological mechanism of bone resorption, mediated not by osteoclasts in subosteoclastic space, but rather by the uncontrolled activity of macrophages in extracellular space.
118
•Journal Article
Tumor necrosis factor-alpha (TNF-alpha) in loosening of total hip replacement (THR).
Xu Jw,Yrjö T. Konttinen,Jan Lassus,Natah S,A Ceponis,Svetlana Solovieva,Aspenberg P,Seppo Santavirta +7 more
TL;DR: Findings suggest that the foreign body-type host reaction caused by THR is characterized by the high expression of TNF-alpha, which may contribute to periprosthetic osteolysis and to the loosening of THR.
104
Relation of p53 tumor suppressor protein expression to human papillomavirus (HPV) DNA and to cellular atypia in male genital warts and in premalignant lesions.
TL;DR: The results show that a few cells in male genital warts even with no cellular atypia may express abnormally sequestered or loss-of-function p53 protein, and that concomitant presence of any type of HPV DNA is associated with recurrencies or progression of premalignant changes.
25
Dendritic cells in rheumatoid synovial membrane after total removal of the hyaline articular cartilage
Tian-Fang Li,Jami Mandelin,M Hukkanen,Jan Lassus,J. Sandelin,Seppo Santavirta,Ismo Virtanen,Yrjö T. Konttinen +7 more
TL;DR: Removal of the hyaline articular cartilage reduces the infiltration and functional differentiation of dendritic cells in synovial membrane, and suggests that the antigen driving chronic arthritis/synovitis is contained in the hyalinistic cartilage.