Jan Kajstura
Brigham and Women's Hospital
217 Papers
3.5K Citations
Jan Kajstura is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Myocyte & Stem cell. The author has an hindex of 98, co-authored 217 publications. Previous affiliations of Jan Kajstura include University of Louisville & Harvard University.
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Papers
Nuclear Targeting of Akt Enhances Kinase Activity and Survival of Cardiomyocytes
Isao Shiraishi,Jaime Melendez,Youngkeun Ahn,Maryanne Skavdahl,Elizabeth Murphy,Sara Welch,Erik Schaefer,Kenneth Walsh,Anthony Rosenzweig,Daniele Torella,Daria Nurzynska,Jan Kajstura,Annarosa Leri,Piero Anversa,Mark A. Sussman +14 more
TL;DR: Experiments show that targeting of Akt to the nucleus mediates inhibition of apoptosis without hypertrophic remodeling, opening new possibilities for therapeutic applications of nuclear-targeted AkT to inhibit cell death associated with heart disease.
Programmed Myocyte Cell Death Affects the Viable Myocardium after Infarction in Rats
Wei Cheng,Jan Kajstura,James A. Nitahara,Baosheng Li,Krzysztof Reiss,Yu Liu,William A. Clark,Stanislaw Krajewski,John C. Reed,Giorgio Olivetti,Piero Anversa +10 more
TL;DR: The mechanical load produced by myocardial infarction and ventricular failure may affect the regulation of bcl-2 and bax in the viable myocytes, triggering programmed cell death and the remodeling of the ventricular wall.
Functionally Competent Cardiac Stem Cells Can Be Isolated From Endomyocardial Biopsies of Patients With Advanced Cardiomyopathies
Domenico D'Amario,Claudia Fiorini,Patricia Campbell,Polina Goichberg,Fumihiro Sanada,Hanqiao Zheng,Toru Hosoda,Marcello Rota,John M. Connell,Robert P. Gallegos,Frederick G.P. Welt,Michael M. Givertz,Richard N. Mitchell,Annarosa Leri,Jan Kajstura,Marc A. Pfeffer,Piero Anversa +16 more
TL;DR: The growth properties of mC SCs and vCSCs isolated from endomyocardial biopsies from patients with advanced heart failure were comparable to those obtained previously from larger myocardial samples of patients undergoing elective cardiac surgery.
Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function
Antonella De Angelis,Elena Piegari,Donato Cappetta,Laura Marino,Amelia Filippelli,Liberato Berrino,João Ferreira-Martins,Hanqiao Zheng,Toru Hosoda,Marcello Rota,Konrad Urbanek,Jan Kajstura,Annarosa Leri,Francesco Rossi,Piero Anversa +14 more
TL;DR: The results raise the possibility that autologous CPCs can be obtained before antineoplastic drugs are given to cancer patients and subsequently administered to individuals who are particularly sensitive to the cardiotoxicity of these agents for prevention or management of heart failure.
Proliferating Cell Nuclear Antigen (PCNA), DNA Synthesis and Mitosis in Myocytes Following Cardiac Transplantation in Man☆
Carlo Alberto Beltrami,Carla Di Loreto,Nicoletta Finato,Maurizio Rocco,Daria Artico,Elena Cigola,Steven R. Gambert,Giorgio Olivetti,Jan Kajstura,Piero Anversa +9 more
TL;DR: The results suggest that the evolution of the transplanted heart involves the expression of a gene which is implicated in DNA replication, and the notion that proliferation of myocytes and non muscle cells may be a component of ventricular remodeling after cardiac transplantation.