Jan E. Doran
Georgia Regents University
10 Papers
140 Citations
Jan E. Doran is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Sepsis & Alkaline phosphatase. The author has an hindex of 8, co-authored 10 publications.
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Papers
Reconstituted high density lipoprotein inhibits physiologic and tumor necrosis factor α responses to lipopolysaccharide in rabbits
Jorge I. Cué,Joseph T. DiPiro,Joseph T. DiPiro,Lane J. Brunner,Jan E. Doran,Mark E. Blankenship,Arlie R. Mansberger,Michael L. Hawkins +7 more
TL;DR: Reconstituted human high density lipoprotein appears to be useful in inhibiting the physiologic effects and cytokine release associated with endotoxemia and may provide adjunctive treatment for patients with gram-negative sepsis.
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Clinical response to cold insoluble globulin replacement in a patient with sepsis and thermal injury.
TL;DR: A relatively simple bioassay developed at the Medical College of Georgia substantiated that cold insoluble globulin is severely depleted in sepsis and a septic patient's response to infusion of cold insoluable globulin are reported herein.
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The influence of fibronectin administration on the incidence of sepsis and septic mortality in severely injured patients
Arlie R. Mansberger,Jan E. Doran,R. C. Treat,M. Hawkins,J. R. May,B. D. Callaway,M. Horowitz,B. Horowitz,R. Shulman +8 more
TL;DR: It is suggested that exogenous Fn repletion in states of deficiency does not alter clinical course, the development of sepsis, or septic mortality, and is not associated with organ function parameters.
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A Competitive Inhibition Assay for Gelatin Binding Fibronectin
TL;DR: The assay described is quick, quantitative, and reproducible, and satisfies the need for a measure of functional Fn activity in the clinical laboratory, and is resistant to interference by normal plasma proteins.
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Effect of cholecystectomy on cold insoluble globulin.
TL;DR: Using a new, rapid bioassay, it is demonstrated that in humans subjected to operative trauma, circulating CIG levels are considerably depressed in the early hours after operation and return to normal within 24 hours.
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