Jan A. Nguyen
Johns Hopkins University School of Medicine
6 Papers
Jan A. Nguyen is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Mycobacterium abscessus & Nontuberculous mycobacteria. The author has an hindex of 1, co-authored 4 publications.
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Papers
Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection.
Rebekah M. Dedrick,Krista G. Freeman,Jan A. Nguyen,Asli Bahadirli-Talbott,Bailey E. Smith,Andrew E. Wu,Aaron S. Ong,Cheng Ting Lin,Lisa C. Ruppel,Nicole Parrish,Graham F. Hatfull,Keira A. Cohen +11 more
TL;DR: In this article, an 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain.
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Global phylogenomic analyses of Mycobacterium abscessus provide context for non cystic fibrosis infections and the evolution of antibiotic resistance.
Ryan A. Bronson,Chhavi Gupta,Abigail L. Manson,Jan A. Nguyen,Asli Bahadirli-Talbott,Nicole Parrish,Ashlee M. Earl,Keira A. Cohen +7 more
TL;DR: In this paper, the authors construct a global dataset of 1,279 MAB whole genomes from CF or non-CF patients and utilize whole genome analysis to assess relatedness, phylogeography, and drug resistance evolution.
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Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
Rebekah M. Dedrick,K. Freeman,Jan A. Nguyen,Asli Bahadirli-Talbott,M. Cardin,Madison Cristinziano,Bailey E. Smith,Soo Jeong Jeong,Elisa Ignatius,Cheng Ting Lin,Keira A. Cohen,Graham F. Hatfull +11 more
TL;DR: An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy, and subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Myc Cobacterium burden.