Jami Shaffer
Ohio State University
9 Papers
7 Citations
Jami Shaffer is an academic researcher from Ohio State University. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 2, co-authored 4 publications.
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Papers
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation
Zachary A. Hing,Janek S. Walker,E. Whipp,Lindsey T. Brinton,Matthew Cannon,Pu Zhang,S. Sher,Casey Cempre,Fiona Brown,Porsha Smith,Claudio Agostinelli,Stefano Pileri,Jordan N. Skinner,Katie L. Williams,Hannah Phillips,Jami Shaffer,Larry P Beaver,Alexander Pan,Kyle Shin,C. Thomas Gregory,Gulcin Ozer,Selen A. Yilmaz,Bonnie K. Harrington,Amy Lehman,Lianbo Yu,Vincenzo Coppola,Pearlly S. Yan,Peggy Scherle,Min Wang,Philip Pitis,Chaoyi Xu,Kris Vaddi,Selina Chen-Kiang,Jennifer A. Woyach,James S. Blachly,Lapo Alinari,Yiming Yang,John C. Byrd,Robert A. Baiocchi,Bradley W. Blaser,Rosa Lapalombella +40 more
TL;DR: In this paper , a SAM-competitive protein arginine methyltransferase 5 (PRMT5) inhibitor, PRT382, was proposed to drive oncogenic pathways promoting Richter's Transformation.
Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C.
Vera Binder,Wantong Li,Muhammad Faisal,Konur Oyman,Donn L Calkins,Jami Shaffer,Emily M Teets,S. Sher,Alexandra Belardo,William Deruelle,Shelley Orwick,Elliott J. Hagedorn,Julie R. Perlin,Serine Avagyan,Asher Lichtig,Francesca G. Barrett,Michelle Ammerman,Song Yang,Yi Zhou,William E. Carson,Heather R. Shive,James S. Blachly,Rosa Lapalombella,Leonard I. Zon,Bradley W. Blaser +24 more
TL;DR: In this paper , the authors demonstrate the existence of reserve capacity within the sinusoidal vascular niche that is controlled by CXCL8 and PKC and have significant impact on HSC phylogenetic and phenotypic fate.
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Cxcl8 Expands Hematopoietic Stem and Progenitor Cells and Alters Their Interaction with the Endothelial Niche
Donn L Calkins,Jami Shaffer,Emily M Teets,Alex M Belardo,Serine Avagyan,Leonard I. Zon,Bradley W. Blaser +6 more
TL;DR: Overexpression of cxcl8 by HSPCs increased HSPC-endothelial cell cuddling time by 30% and was suggested a possible mechanism to explain the increased CHT residency time.
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Quantifying Hematopoietic Stem Cell Clonal Diversity by Selecting Informative Amplicon Barcodes.
TL;DR: An analytical framework, Selection of informative Amplicon Barcodes from Experimental Replicates (SABER), that identifies barcodes that are unique among a large set of experimental replicates that reproducibly quantifies functional HSCs and can accommodate a wide range of experimental group sizes is developed.
Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase.
Himanshu Savardekar,Carter Allen,H. Jeon,Jianying Li,Dionisia Quiroga,E. Schwarz,Richard C Wu,Sara Zelinskas,Gabby Lapurga,Alexander Abreo,Andrew Stiff,Jami Shaffer,Bradley W. Blaser,Matthew Old,Robert Wesolowski,Gang Xin,Kari L Kendra,Dongjun Chung,William E Carson +18 more
TL;DR: Single-cell RNA sequencing analysis reveals that BTK inhibition with ibrutinib downregulates key genes and pathways in myeloid-derived suppressor cells from cancer patients, particularly in melanoma, enhancing antitumor activity of anti-PD-1 antibody treatments.
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