James Wright
GlaxoSmithKline
4 Papers
33 Citations
James Wright is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: TRPV1 & Chemistry. The author has an hindex of 4, co-authored 4 publications.
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Papers
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
Graham D Smith,Martin J. Gunthorpe,Rosemary E. Kelsell,Philip David Hayes,P. Reilly,Paul Facer,James Wright,Jeffrey C. Jerman,Jean-Philippe Walhin,Lezanne Ooi,Julie Egerton,K. J. Charles,Darren Smart,Andrew D. Randall,Praveen Anand,John B. Davis +15 more
TL;DR: A member of the vanilloid receptor/TRP gene family, vanilloids receptor-like protein 3 (VRL3, also known as TRPV3), is identified, which is heat-sensitive but capsaicin-insensitive, suggesting the existence of thermosensitive receptors distinct from VR1.
872
Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1
Susan Marie Westaway,Mervyn Thompson,Harshad Kantilal Rami,Geoffrey Stemp,Leontine Saskia Trouw,Darren Jason Mitchell,Jon T. Seal,Stephen J. Medhurst,Sarah C. Lappin,James Biggs,James Wright,Sandra Arpino,Jeffrey C. Jerman,Jennifer E. Cryan,Vicky Holland,Kim Winborn,Tanya Coleman,Alexander J. Stevens,John B. Davis,Martin J. Gunthorpe +19 more
TL;DR: The discovery of 6-(4-fluorophenyl)-2- methyl-N-(2-methylbenzothiazol-5-yl)nicotinamide which possesses an excellent overall profile and has been progressed into pre-clinical development.
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N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.
Susan Marie Westaway,Ying-Kit Chung,John B. Davis,Vicky Holland,Jeffrey C. Jerman,Stephen J. Medhurst,Harshad Kantilal Rami,Geoffrey Stemp,Alexander J. Stevens,Mervyn Thompson,Kim Winborn,James Wright +11 more
TL;DR: The N-quinolinylnicotinamide showed excellent potency at human, guinea pig and rat TRPV1, a favourable in vitro DMPK profile and activity in an in vivo model of inflammatory pain.
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Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor
TL;DR: The data suggest that noladin ether is acting at a prejunctional site and no interaction with TRPV1 is involved, and in mesenteric beds from pertussis toxin (PTX)‐pretreated rats, the inhibitory actions of noladdin ether on sensory neurotransmission were abolished, indicating the involvement of Gi/o protein‐coupled receptors.