James Winter
University of Birmingham
34 Papers
115 Citations
James Winter is an academic researcher from University of Birmingham. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 27 publications. Previous affiliations of James Winter include King's College London & University of Leicester.
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Papers
Mechanisms underlying the autonomic modulation of ventricular fibrillation initiation—tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure
TL;DR: There is a significant body of evidence from experimental and clinical studies, demonstrating that the vagus nerve has an anti-arrhythmic action, protecting against induced and spontaneously occurring ventricular arrhythmias.
The mechanical uncoupler blebbistatin is associated with significant electrophysiological effects in the isolated rabbit heart.
TL;DR: This new finding significantly affects cardiac ventricular electrophysiology and induction of ventricular fibrillation and has serious implications for optical mapping studies where blebbistatin is used to inhibit cardiac contraction.
ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology
Christopher O’Shea,Andrew P. Holmes,Ting Y. Yu,James Winter,S. Wells,S. Wells,Joao Correia,Bastiaan J. Boukens,Joris R. de Groot,Gavin S Chu,Gavin S Chu,Xin Li,G. André Ng,G. André Ng,Paulus Kirchhof,Larissa Fabritz,Kashif Rajpoot,Davor Pavlovic +17 more
TL;DR: ElectroMap is presented, an adaptable, high-throughput, open-source software for processing, analysis and mapping of complex electrophysiology datasets from diverse experimental models and acquisition modalities, employing multiple methodologies currently not widely available to researchers.
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Cardiac Optogenetics and Optical Mapping - Overcoming Spectral Congestion in All-Optical Cardiac Electrophysiology.
Christopher O’Shea,Andrew P. Holmes,James Winter,Joao Correia,Xianhong Ou,Ruirui Dong,Shicheng He,Paulus Kirchhof,Larissa Fabritz,Kashif Rajpoot,Davor Pavlovic +10 more
TL;DR: This review provides a synopsis of optogenetics and discusses in detail its use and compatibility with optical interrogation of cardiac electrophysiology, and focuses on state-of-the-art setup design, challenges in light delivery and filtering, and compatibility of opsins with fluorescent reporters used in optical mapping.
Restitution slope is principally determined by steady-state action potential duration.
Michael J. Shattock,Kyung Chan Park,Hsiang-Yu Yang,Angela W.C. Lee,Steven A. Niederer,Kenneth T. MacLeod,James Winter +6 more
TL;DR: Steady-state APD is the principal determinant of the slope of the ventricular electrical restitution curve and concomitant changes in tissue refractoriness act to reduce susceptibility to sustained VF.
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