James W. Patrick
Baylor College of Medicine
23 Papers
534 Citations
James W. Patrick is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Nicotinic agonist & Receptor. The author has an hindex of 20, co-authored 23 publications.
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Papers
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
Avi Orr-Urtreger,Finn M. Göldner,Mayuko Saeki,Isabel Lorenzo,Leah Goldberg,Mariella De Biasi,John A. Dani,James W. Patrick,Arthur L. Beaudet +8 more
TL;DR: It is demonstrated that the α7 subunit is not essential for normal development or for apparently normal neurological function, but the mice may prove to have subtle phenotypic abnormalities and will be valuable in defining the functional role of this gene product in vivo.
502
α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice
Richard Paylor,Michelle Nguyen,Jacqueline N. Crawley,James W. Patrick,Arthur L. Beaudet,Arthur L. Beaudet,Avi Orr-Urtreger,Avi Orr-Urtreger +7 more
TL;DR: The results of this study show that the absence of alpha7 nAChRs has little impact on normal, base-line behavioral responses, and future studies will examine the contribution ofalpha7nAChR to the enhancement of learning and sensorimotor gating following nicotine treatments.
Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors.
Wei Xu,Avi Orr-Urtreger,Filippo Nigro,Shari E. Gelber,Cara Ballard Sutcliffe,Dawna L. Armstrong,James W. Patrick,Lorna W. Role,Arthur L. Beaudet,Mariella De Biasi +9 more
TL;DR: The previous description of a similar phenotype in α3−/− mice and the current data suggest that the α3 and the β4 subunits are major components in autonomic nAChRs.
276
The α-Bungarotoxin-binding Nicotinic Acetylcholine Receptor from Rat Brain Contains Only the α7 Subunit
DaNong Chen,James W. Patrick +1 more
TL;DR: Experimental data support the current working hypothesis that the α-bungarotoxin-binding nicotinic receptor is a homo-oligomer of α7 subunits in the rat brain.
204
Pharmacology of Neuronal Nicotinic Acetylcholine Receptor Subtypes
TL;DR: The search for the physiological function of nicotinic receptors on neurons in the brain began with their discovery and the best functional evidence now points to a role in modifying the release of other transmitters.
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