James Torpy
Garvan Institute of Medical Research
4 Papers
1 Citations
James Torpy is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Cellular differentiation & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
Cindy S. Ma,Cindy S. Ma,Natalie Wong,Geetha Rao,Danielle T. Avery,James Torpy,Thomas Hambridge,Jacinta Bustamante,Satoshi Okada,Jennifer Stoddard,Elissa K. Deenick,Elissa K. Deenick,Simon J. Pelham,Simon J. Pelham,Kathryn Payne,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Anne Puel,Masao Kobayashi,Peter D. Arkwright,Sara Sebnem Kilic,Jamila El Baghdadi,Shigeaki Nonoyama,Yoshiyuki Minegishi,Seyed Alireza Mahdaviani,Davood Mansouri,Aziz Bousfiha,Annaliesse Blincoe,Martyn A. French,Martyn A. French,Peter Hsu,Dianne E. Campbell,Michael Stormon,Melanie Wong,Stephen Adelstein,Joanne Smart,David A. Fulcher,Matthew C. Cook,Matthew C. Cook,Tri Giang Phan,Tri Giang Phan,Polina Stepensky,Kaan Boztug,Kaan Boztug,Aydan Kansu,Aydan Ikinciogullari,Ulrich Baumann,Rita Beier,Tony Roscioli,Tony Roscioli,John B. Ziegler,Paul Gray,Capucine Picard,Bodo Grimbacher,Klaus Warnatz,Steven M. Holland,Jean-Laurent Casanova,Gulbu Uzel,Stuart G. Tangye,Stuart G. Tangye +59 more
TL;DR: Findings shed new light on TFH cell biology and the integrated signaling pathways required for their generation, maintenance, and effector function and explain the compromised humoral immunity seen in patients with some PIDs.
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Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
Cindy S. Ma,Natalie Wong,Geetha Rao,Akira Nguyen,Danielle T. Avery,Kathryn Payne,James Torpy,Patrick O’Young,Elissa K. Deenick,Jacinta Bustamante,Anne Puel,Anne Puel,Satoshi Okada,Masao Kobayashi,Rubén Martínez-Barricarte,Michael Elliott,Michael Elliott,Sara Sebnem Kilic,Jamila El Baghdadi,Yoshiyuki Minegishi,Aziz Bousfiha,Nic Robertson,Sophie Hambleton,Peter D. Arkwright,Martyn A. French,Martyn A. French,Annaliesse Blincoe,Peter Hsu,Dianne E. Campbell,Michael Stormon,Melanie Wong,Stephen Adelstein,Stephen Adelstein,David A. Fulcher,Matthew C. Cook,Polina Stepensky,Kaan Boztug,Kaan Boztug,Rita Beier,Aydan Ikinciogullari,John B. Ziegler,Paul Gray,Capucine Picard,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Tri Giang Phan,Bodo Grimbacher,Klaus Warnatz,Steven M. Holland,Gulbu Uzel,Jean-Laurent Casanova,Stuart G. Tangye +52 more
TL;DR: Tangye and collaborators use a series of mutants to elucidate the pathways required to generate distinct subsets of human effector CD4+ T cells.
A quantitative universal NGS-based circulating tumor DNA assay for hepatoblastoma
Smadar Kahana-Edwin,James Torpy,Lucy E. Cain,Alan Mullins,G McCowage,Sarah E. Woodfield,Swetha Vasudevan,D. Shea,André E. Minoche,S. Kummerfeld,LC Goldstein,Jonathan Karpelowsky +11 more
TL;DR: Approximate quantitation of various variants including single base substitutions and deletions down to 0.3% variant allele frequency is demonstrated to allow biopsy-free tumor genotyping and sensitive ct DNA quantitation, providing promising evidence for the utility of quantitative ctDNA detection in hepatoblastoma.
A quantitative risk assessment for the incursion of lumpy skin disease virus into Australia via long-distance windborne dispersal of arthropod vectors.
Robyn N. Hall,James Torpy,Rachel Nye,E. Zalcman,B Cowled +4 more
TL;DR: A quantitative risk assessment for lumpy skin disease virus (LSDV) incursion into Australia via windborne dispersal of arthropod vectors estimated a low risk, with a median incursion rate of one every 403 years, but increased to 7-8 years with single-insect transmission and negligible risk with multiple-insect transmission.