James T. Powell
8 Papers
23 Citations
James T. Powell is an academic researcher. The author has contributed to research in topics: Unfolded protein response & Neuroprotection. The author has an hindex of 8, co-authored 8 publications.
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Papers
L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential.
TL;DR: Dosing of animals with L- Serine and human clinical trials investigating the therapeutic effects of L-serine support the FDA’s determination that L-Serine is generally regarded as safe (GRAS); it also appears to be neuroprotective.
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l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND.
David A. Davis,Paul Alan Cox,Sandra Anne Banack,Patricia D Lecusay,Susanna P. Garamszegi,Matthew J Hagan,James T. Powell,James S. Metcalf,Roberta M. Palmour,Roberta M. Palmour,Amy Beierschmitt,Amy Beierschmitt,Walter G. Bradley,Deborah C. Mash,Deborah C. Mash +14 more
TL;DR: It is demonstrated that chronic dietary exposure to BMAA causes ALS/MND-type pathological changes in the vervet and coadministration of l-serine reduces the amount of reactive gliosis and the number of protein inclusions in motor neurons.
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l-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI)
TL;DR: It is reported that l-serine selectively increased protein disulfide isomerase (PDI) protein translation, an ER chaperone involved in refolding misfolded proteins, suggesting it may be modulating the UPR to favor recovery from ER stress.
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Analysis of Neurotoxic Amino Acids from Marine Waters, Microbial Mats, and Seafood Destined for Human Consumption in the Arabian Gulf
Aspassia D. Chatziefthimiou,Eric J. Deitch,William B. Glover,James T. Powell,Sandra Anne Banack,Renee Richer,Paul Alan Cox,James S. Metcalf +7 more
TL;DR: The findings of this study suggest that exposure to neurotoxic amino acids through seafood in the Arabian Gulf may be minor, yet the presence of BMAA in phytoplankton confirms the need for further monitoring of marine waters and seafood to protect human health.
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Mechanisms of l-Serine Neuroprotection in vitro Include ER Proteostasis Regulation
TL;DR: It is proposed that l-serine may be functioning as a small proteostasis regulator, in effect altering the cells to quickly respond to a possible oxidative insult, thus favoring a return to homeostasis.
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