James T. Lim
5 Papers
James T. Lim is an academic researcher. The author has contributed to research in topics: Biology & Biological network. The author has an hindex of 1, co-authored 3 publications.
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Papers
Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma
Jiawen Yang,James T. Lim,Paul Victor,Chen Chen,Hunain Khwaja,Rick G Schnellmann,Denise J Roe,Prafulla C Gokhale,J.A. DeCaprio,Megha Padi +9 more
TL;DR: Pyrvinium not only reverses the neuroendocrine features of MCC by modulating canonical and non-canonical WNT signaling pathways but also inhibits cancer cell growth by activating the p53-mediated apoptosis pathway, disrupting mitochondrial function, and inducing endoplasmic reticulum (ER) stress.
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Abstract 4882: Multi-omics analysis of mechanisms underlying sensitivity of Merkel cell carcinoma to pyrvinium pamoate
TL;DR: Yang et al. as mentioned in this paper investigated the anti-proliferation and pro-apoptosis effects of pyrvinium pamoate in MCC cell lines and found that PP effectively inhibits proliferation of MCC at concentrations as low as 100 nM and in a dose and time dependent manner.
The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks
Marouen Ben Guebila,Tian Wang,Camila M. Lopes-Ramos,Viola Fanfani,Des Weighill,Rebekka Burkholz,Daniel Schlauch,Joseph N. Paulson,Michael Altenbuchinger,K. Shutta,Abhijeet R. Sonawane,James T. Lim,Genís Calderer,David G.P. van IJzendoorn,Daniel Morgan,Alessandro Marin,Cho Yi Chen,Qi Song,Enakshi Saha,Dawn L. DeMeo,Megha Padi,John Platig,Marieke L. Kuijjer,Kimberly Glass,John Quackenbush +24 more
TL;DR: The Network Zoo as mentioned in this paper is a collection of open-source methods to infer gene regulatory networks, conduct differential network analyses, estimate community structure, and explore the transitions between biological states, and demonstrate the utility using multi-omic data from the Cancer Cell Line Encyclopedia.
The Network Zoo: a multilingual package for the inference and analysis of biological networks
Marouen Ben Guebila,Tian Wang,Camila M. Lopes-Ramos,Viola Fanfani,Deborah Weighill,Rebekka Burkholz,Daniel Schlauch,Joseph N. Paulson,Michael Altenbuchinger,Abhijeet Sonanwane,James T. Lim,Genís Calderer,David G.P. van IJzendoorn,Daniel Morgan,Alessandro Marin,Cho Yi Chen,A. Song,K. Shutta,Dawn L. DeMeo,Megha Padi,John Platig,Marieke L. Kuijjer,Kimberly Glass,John Quackenbush +23 more
TL;DR: The netZoo toolkit analyzed the multi-omic data from the Cancer Cell Line Encyclopedia by inferring gene regulatory networks for each cancer cell line and associating network features with other phenotypic attributes such as drug sensitivity to identify transcription factors that play a critical role in both drug resistance and cancer development in melanoma.
Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma.
Jiawen Yang,James T. Lim,Paul Victor Santiago Raj,Marcelo G. Corona,Chen Chen,Hunain Khawaja,Qiong Pan,Gillian D. Paine-Murrieta,Rick G. Schnellmann,Denise J. Roe,Prafulla C Gokhale,James A. DeCaprio,Megha Padi +12 more