James T. Brash
UCL Institute of Ophthalmology
14 Papers
13 Citations
James T. Brash is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Angiogenesis & Medicine. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of James T. Brash include Imperial College London.
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Papers
VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.
Alessandro Fantin,Anastasia Lampropoulou,Valentina Senatore,James T. Brash,Claudia Prahst,Clemens Lange,Sidath E. Liyanage,Claudio Raimondi,James W B Bainbridge,Hellmut G. Augustin,Hellmut G. Augustin,Christiana Ruhrberg +11 more
TL;DR: It is shown that VEGF165-induced vascular leakage requires both VEGFR2 and NRP1, but not the known NCD interactor GIPC1, which raises the possibility that targeting N RP1 or its N CD interactors may be a useful therapeutic strategy in neovascular disease to reduce VEGf165- induced edema without compromising vessel growth.
NRP1 function and targeting in neurovascular development and eye disease.
TL;DR: An overview of current knowledge of the signalling pathways that are modulated by NRP1 is provided, with particular focus on neuronal and vascular roles in the brain and retina, and the potential of N RP1 inhibitors for the treatment for neovascular eye diseases is discussed.
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Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion
James T. Brash,Rebecca L. Bolton,Victoria S. Rashbrook,Laura Denti,Yoshiaki Kubota,Christiana Ruhrberg +5 more
TL;DR: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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Use of the HPRT gene to study nuclease-induced DNA double-strand break repair
Polly Gravells,Sara Ahrabi,Rajani K. Vangala,Kazunori Tomita,James T. Brash,Lena A. Brustle,Christopher Chung,Julia M. Hong,Aikaterini Kaloudi,Timothy C. Humphrey,Andrew C.G. Porter +10 more
TL;DR: Using a single endogenous reporter gene, the X-chromosomal disease gene encoding hypoxanthine phosphoribosyltransferase (HPRT), the relative utilization of three DSBR pathways following cleavage by I-SceI or CRISPR/Cas9 nucleases is monitored.
Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study
Junqing Xie,James T. Brash,C. Turkmen,Stefan Driessen,Giustino Varrassi,George Argyriou,Sarah Seager,Christian G. Reich,Daniel Prieto-Alhambra +8 more
TL;DR: In this article , the authors investigated whether ibuprofen use, compared with other non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs), cyclooxygenase-2 inhibitors (COX-2i) or paracetamol, increases the risk of coronavirus disease 2019 (COVID-19) diagnosis or hospitalisation.