James R. Gilbert
University of California, San Diego
6 Papers
70 Citations
James R. Gilbert is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Transduction (genetics) & Genetic enhancement. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of James R. Gilbert include Louisiana State University.
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Papers
Identification of a Human Immunodeficiency Virus Type 2 (HIV-2) Encapsidation Determinant and Transduction of Nondividing Human Cells by HIV-2-Based Lentivirus Vectors
TL;DR: It is found that a larger deletion abrogates encapsidation and replication but does not diminish mRNA expression, and a replication-defective, envelope-pseudotyped, three-plasmid HIV-2 lentivirus vector system is incorporated.
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Targeting Vascular Injury Using Hantavirus-Pseudotyped Lentiviral Vectors
Zhong Qian,Makalah Haessler,Julio A. Lemos,Jody R. Arsenault,Jennifer E. Aguirre,James R. Gilbert,Russell P. Bowler,Frank Park +7 more
TL;DR: Data show that LV pseudotyped with Hantaviral glycoproteins can be a useful vector for targeting therapeutic genes to the vasculature in vivo.
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Transduction of Cell Lines and Primary Cells by FIV-Packaged HIV Vectors
TL;DR: It is demonstrated that packaging HIV vectors with FIV is a viable alternative, which avoids use of HIV structural proteins, and to remove the possibility of seroconversion to HIV proteins.
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Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina.
Lingyun Cheng,Sunan Chaidhawangul,Flossie Wong-Staal,James R. Gilbert,Eric M. Poeschla,Mitsuko Toyoguchi,Mohamed H El-Bradey,Germaine Bergeron-Lynn,Kelly A Soules,William R. Freeman +9 more
TL;DR: The HIV-2 viral vector demonstrated efficient gene transfer into many types of retinal cells without apparent cytotoxicity and may be a useful gene delivery vehicle for retinal photoreceptor cells and ganglion cells.
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HIV-2 and SIV vector systems.
TL;DR: How unique features of HIV-2 and SIV are well suited to vector design is pointed to, hoping to leave the reader with a greater appreciation of the potential these viruses offer within the field of gene transfer applications.
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