James O'Beirne
University of the Sunshine Coast
174 Papers
496 Citations
James O'Beirne is an academic researcher from University of the Sunshine Coast. The author has contributed to research in topics: Liver transplantation & Medicine. The author has an hindex of 37, co-authored 165 publications. Previous affiliations of James O'Beirne include Royal Free London NHS Foundation Trust & Royal Sussex County Hospital.
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Papers
Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade
Philip J. Johnson,Sarah Berhane,Chiaki Kagebayashi,Shinji Satomura,M Teng,Helen L. Reeves,James O'Beirne,Richard Fox,Anna Skowronska,D. Palmer,Winnie Yeo,Frankie Mo,Paul B.S. Lai,Mercedes Iñarrairaegui,Stephen L. Chan,Bruno Sangro,Rebecca A. Miksad,Toshifumi Tada,Takashi Kumada,Hidenori Toyoda +19 more
TL;DR: The ALBI grade offers a simple, evidence-based, objective, and discriminatory method of assessing liver function in HCC that has been extensively tested in an international setting and eliminates the need for subjective variables such as ascites and encephalopathy, a requirement in the conventional C-P grade.
Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
Amit C. Nathwani,Edward G. D. Tuddenham,Savita Rangarajan,Cecilia Rosales,Jenny McIntosh,David C. Linch,Pratima Chowdary,Anne Riddell,Arnulfo Jaquilmac Pie,Chris Harrington,James O'Beirne,Keith Smith,John Pasi,Bertil Glader,Pradip Rustagi,Catherine Y.C. Ng,Mark A. Kay,Junfang Zhou,Yunyu Spence,Christopher L. Morton,James A. Allay,John Coleman,Susan Sleep,John M. Cunningham,Deokumar Srivastava,Etiena Basner-Tschakarjan,Federico Mingozzi,Katherine A. High,John T. Gray,Ulrike M. Reiss,Arthur W. Nienhuis,Andrew M. Davidoff +31 more
TL;DR: Peripheral-vein infusion of scAAV2/8-LP1-hFIXco resulted in FIX transgene expression at levels sufficient to improve the bleeding phenotype, with few side effects.
A simple prognostic scoring system for patients receiving transarterial embolisation for hepatocellular cancer.
L. Kadalayil,R. Benini,L Pallan,James O'Beirne,Laura Marelli,Dominic Yu,Allan Hackshaw,Richard Fox,Philip J. Johnson,A.K. Burroughs,Daniel H. Palmer,Tim Meyer +11 more
TL;DR: The HAP score predicts outcomes in patients with HCC undergoing TACE/TAE and may help guide treatment selection, allow stratification in clinical trials and facilitate meaningful comparisons across reported series.
347
Reduced exposure to calcineurin inhibitors early after liver transplantation prevents recurrence of hepatocellular carcinoma
Manuel Rodríguez-Perálvarez,Emmanuel Tsochatzis,María Carmen Naveas,G. Pieri,Carmen García-Caparrós,James O'Beirne,Antonio Poyato-González,Gustavo Ferrín-Sánchez,José Luis Montero-Álvarez,David Patch,Douglas Thorburn,Javier Briceño,Manuel de la Mata,Andrew K. Burroughs +13 more
TL;DR: Investigation of immunosuppression protocols with early CNI minimization should be preferred in LT patients with HCC in order to minimize tumour recurrence.
231
Long-term impact of liver function on curative therapy for hepatocellular carcinoma: application of the ALBI grade
Hidenori Toyoda,Paul B.S. Lai,James O'Beirne,Charing C Chong,Sarah Berhane,Helen L. Reeves,Derek Manas,Richard Fox,Winnie Yeo,Frankie Mo,Anthony W.H. Chan,Toshifumi Tada,Mercedes Iñarrairaegui,Arndt Vogel,Nora Schweitzer,Stephen L. Chan,Bruno Sangro,Takashi Kumada,Philip J. Johnson,Philip J. Johnson +19 more
TL;DR: The ALBI score represents a simple approach to the assessment of liver function in patients with HCC and suggests that ALBI grade-1 patients are appropriately treated with surgical resection whereas ALBIgrade-2 patients may, where the option exists, be more suitable for liver transplantation or the less invasive curative ablative therapies.