James McCulloch
United States Public Health Service
17 Papers
391 Citations
James McCulloch is an academic researcher from United States Public Health Service. The author has contributed to research in topics: Cerebral blood flow & Dopaminergic. The author has an hindex of 15, co-authored 17 publications. Previous affiliations of James McCulloch include National Institutes of Health.
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Papers
Recirculation model following MCA occlusion in rats. Cerebral blood flow, cerebrovascular permeability, and brain edema.
TL;DR: A new model for establishing a successful and consistent arterial recirculation has been devised following middle cerebral artery (MCA) occlusion in the rat and further study is required to determine thresholds of ischemic brain damage and edema formation at recirculated following focal cerebral ischemia.
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Distribution of effects of haloperidol on energy metabolism in the rat brain.
TL;DR: The effects of the putative dopaminergic antagonist, haloperidol, on cerebral glucose utilization in 43 anatomically discrete regions of the rat brain have been examined by the quantitative autoradiographic 2-deoxyglucose technique.
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The effects of N-methyl-D-aspartate receptor blockade with MK-801 upon the relationship between cerebral blood flow and glucose utilisation
TL;DR: The local cerebral circulatory and metabolic effects of MK-801, a selective non-competitive N-methyl-D-aspartate receptor antagonist have been examined in conscious rats with quantitative autoradiographic techniques using [ 14C]iodoantipyrine and [14C]2-deoxyglucose as tracers.
81
Endothelin receptor antagonist increases cerebral perfusion and reduces ischaemic damage in feline focal cerebral ischaemia
Toshal R. Patel,Samuel Galbraith,David I. Graham,Hussein Hallak,Annette Marian Doherty,James McCulloch +5 more
TL;DR: The investigations indicate that endothelin receptor antagonism may be a new therapeutic strategy for the amelioration of focal ischaemic damage.
78
Local Cerebral Glucose Utilization in Hypothermic and Hyperthermic Rats
TL;DR: The regional heterogeneity in the alterations in glucose utilization suggests that caution must be exercised in the interpretation of autoradiographic 2‐deoxyglucose investigations in which body temperature disturbances occur.
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