James M. Way

TL;DR: The behavior of transiently transfected human receptors into melanophores and the potential use of constitutive receptor activity to screen for new drug entities are described and the applicability of this approach for the general screening of G protein-coupled orphan receptors is discussed.

TL;DR: Renal, gastric, and cardiac tissues subjected to genomic analysis of expression in perinatal ERRgamma null mice revealed a characteristic dysregulation of genes involved in transport processes, exemplified by the voltage-gated potassium channel, Kcne2.

TL;DR: Analysis of human genomic DNA reveals an intronless sequence with strong homology to human G{alpha}{sub q} cDNA, which includes several small deletions and insertions that alter the reading frame, multiple single base changes, and a premature termination codon in the open readingframe, hallmarks of a processed pseudogene.

TL;DR: Several key challenges in progressing small molecules which target ERRa are identified, including the separation of efficacy and liability.