James Lorens

TL;DR: Intacellular adhesion molecule-2 (ICAM-2) was identified in a genetic screen as an activator of the PI3K/AKT pathway leading to inhibition of apoptosis, and engagement by CD19+ cells of its natural receptor, LFA-1, on CD4+ naive cells specifically induced AKT activity in the absence of an MHC-peptide interaction.

TL;DR: The ability to express protein microdomains can be a powerful means to subtly perturb cellular physiology in manners that reveal new paths for therapeutic intervention, and it is believed that such approaches might allow for new forms of gene therapy to become available.

TL;DR: In this article, the authors proposed methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle Regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.

TL;DR: The TRA99 vectors demonstrate regulated expression with activated levels comparable to those of standard retroviral vectors and repressed levels indistinguishable from background, achieved without using an internal promoter cassette, thus retaining the cis-packaging elements requisite for helper-mediated transfer.