James Lin
Bristol-Myers Squibb
47 Papers
701 Citations
James Lin is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Chemistry & Benzothiazole. The author has an hindex of 23, co-authored 46 publications.
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Papers
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.
Jagabandhu Das,Ping Chen,Derek J. Norris,Ramesh Padmanabha,James Lin,Robert V. Moquin,Zhongqi Shen,Lynda S. Cook,Arthur M. Doweyko,Sidney Pitt,Suhong Pang,Ding Ren Shen,Qiong Fang,Henry F. De Fex,Kim W. McIntyre,David J. Shuster,Kathleen M. Gillooly,Kamelia Behnia,Gary L. Schieven,John Wityak,Joel C. Barrish +20 more
TL;DR: Molecular modeling was used to construct a putative binding model for Lck inhibition by Dasatinib and 12m, and the framework of key hydrogen-bond interactions proposed was in agreement with the subsequent, published crystal structure of 2 bound to structurally similar Abl kinase.
404
A mild and efficient method for the preparation of guanidines
TL;DR: A mild and efficient method for the preparation of guanidines by reaction of an acylated thiourea with an amine followed by removal of the acyl group(s) from the intermediate acylguanidine is reported.
141
Patent
Fused heterocyclic compounds useful as kinase modulators
Wayne Vaccaro,Zhong Chen,Dharmpal S. Dodd,Tram N. Huynh,James Lin,Chunjian Liu,Mussari Christopher P,John S. Tokarski,David R. Tortolani,Stephen T. Wrobleski +9 more
- 22 Sep 2006
TL;DR: In this paper, the authors defined a class of compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically acceptable salts, and hydrates, thereof, which are useful as kinase modulators, including MK2 modulation.
125
Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitors
Jagabandhu Das,Robert V. Moquin,James Lin,Chunjian Liu,Arthur M. Doweyko,Henry F. DeFex,Qiong Fang,Suhong Pang,Sidney Pitt,Ding Ren Shen,Gary L. Schieven,Joel C. Barrish,John Wityak +12 more
TL;DR: Two structurally novel benzothiazole based small molecule inhibitors of p56(lck) are identified as potent Lck inhibitors with excellent cellular activities against T-cell proliferation.
122
Preparation of N,N'-bis-tert-Butoxycarbonylthiourea
TL;DR: In this article, the preparation of N,N'-bis-tert-butoxycarbonylthiourea from thIourea and di-TERT-butyl dicarbonate in tetrahydrofuran is described.
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