James L. Lear
University of Colorado Denver
5 Papers
73 Citations
James L. Lear is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Cancer & Antigen. The author has an hindex of 5, co-authored 5 publications.
Chat about Author
Papers
Functional asplenia in hemoglobin SC disease
Peter A. Lane,Jacquie L. O'Connell,James L. Lear,Zora R. Rogers,Gerald M. Woods,Kathryn L. Hassell,Doris L. Wethers,Dennis W. Luckey,George R. Buchanan +8 more
TL;DR: The data indicate that functional asplenia occurs in many patients with hemoglobin SC disease, but its development is usually delayed until after 4 years of age, and the routine administration of prophylactic penicillin to infants and young children with hemochemistry SC disease may not be necessary.
76
32P Radiosynoviorthesis in Children With Hemophilia
Marilyn J. Manco-Johnson,Rachelle Nuss,James L. Lear,Jerome D. Wiedel,S. Geraghty,Michele R. Hacker,Sharon Funk,Ray F. Kilcoyne,James Murphy +8 more
TL;DR: Radiosynoviorthesis is effective in limiting the frequency of joint hemorrhage, decreasing pain and improving function in children with hemophilia, however, long-term safety studies are needed.
66
•Journal Article
High-Dose 90Y Mx-Diethylenetriaminepentaacetic Acid (DTPA)-BrE-3 and Autologous Hematopoietic Stem Cell Support (AHSCS) for the Treatment of Advanced Breast Cancer: A Phase I Trial
David M. Schrier,Salomon M. Stemmer,Timothy Johnson,Ravindra Kasliwal,James L. Lear,S. Matthes,Sharon Taffs,Christopher Dufton,Stephan D. Glenn,Gregory Butchko,Robert L. Ceriani,Douglas Rovira,Paul A. Bunn,Elizabeth J. Shpall,Scott I. Bearman,Malcom Purdy,Pablo J. Cagnoni,Roy B. Jones +17 more
TL;DR: This Phase I trial explores the use of high-dose 90Y conjugated to the antibreast cancer monoclonal antibody BrE-3 and autologous hematologic cell support in the treatment of women with stage four breast cancer.
60
•Journal Article
Imaging of Non-Small Cell Lung Cancers with a Monoclonal Antibody, KC-4G3, Which Recognizes a Human Milk Fat Globule Antigen
David G. Dienhart,Raymond F. Schmelter,James L. Lear,Gary J. Miller,Stephan D. Glenn,Duane C. Bloedow,Ravindra Kasliwal,Patrick L. Moran,Paul A. Seligman,James R. Murphy,Kenneth Kortright,Paul A. Bunn +11 more
TL;DR: It is concluded that 111In-KC-4G3 demonstrates successful tumor localization in non-small cell lung cancers bearing generally high expression of its antigen and further investigations to diminish nonspecific radioactivity for imaging and utilization of high dose radiolabeled antibody for therapeutic intent are warranted.
10
Splenic function in persons with sickle cell trait at moderately high altitude.
TL;DR: The data suggest that long‐term residence at moderately high altitude does not place persons with sickle cell trait at risk for splenic dysfunction.
10