James H. Fallon
University of California, Irvine
135 Papers
1.8K Citations
James H. Fallon is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Ventral tegmental area & Substantia nigra. The author has an hindex of 55, co-authored 134 publications. Previous affiliations of James H. Fallon include University of California & Salk Institute for Biological Studies.
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Papers
Reproducibility of Quantitative Tractography Methods Applied to Cerebral White Matter
Setsu Wakana,Arvind Caprihan,Martina M. Panzenboeck,James H. Fallon,Michele E. Perry,Randy L. Gollub,Kegang Hua,Jiangyang Zhang,Hangyi Jiang,Hangyi Jiang,Prachi Dubey,Ari M. Blitz,Peter C.M. van Zijl,Peter C.M. van Zijl,Susumu Mori,Susumu Mori +15 more
TL;DR: This protocol provides guidelines for reproducible DTI-based tract-specific quantification for reconstructing major white matter tracts based on diffusion tensor imaging.
1.6K
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Mark H. Tuszynski,Mark H. Tuszynski,Leon J. Thal,Leon J. Thal,Mary Pay,David P. Salmon,Hoi Sang U,Roy A.E. Bakay,Piyush M. Patel,Armin Blesch,H. Lee Vahlsing,H. Lee Vahlsing,Gilbert Ho,Gang Tong,Steven G. Potkin,James H. Fallon,Lawrence A. Hansen,Elliott J. Mufson,Jeffrey H. Kordower,Christine M. Gall,James M. Conner +20 more
TL;DR: A phase 1 trial of ex vivo NGF gene delivery in eight individuals with mild Alzheimer disease, implanting autologous fibroblasts genetically modified to express human NGF into the forebrain found no long-term adverse effects and brain autopsy from one subject suggested robust growth responses to NGF.
1K
Fluoro-gold: a new fluorescent retrograde axonal tracer with numerous unique properties
TL;DR: A new fluorescent dye, Fluoro-Gold, has been demonstrated to undergo retrograde axonal transport and its properties include intense fluorescence, extensive filling of dendrites, high resistance to fading, wide latitude of survival times and compatibility with all other tested neuro-histochemical techniques.
918
In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain.
James H. Fallon,Steve Reid,R. Kinyamu,Isaac O. Opole,Rebecca Opole,Janie Baratta,Murray Korc,Tiffany L. Endo,Alexander Duong,Gemi Nguyen,Masoud Karkehabadhi,Daniel Twardzik,Sandra E. Loughlin +12 more
TL;DR: The results show that the brain contains stem cells capable of PMD in response to an exogenously administered growth factor, which has significant implications with respect to the development of treatments for both acute neural trauma and neurodegenerative diseases.
464
Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness.
TL;DR: A model of anesthetic-induced unconsciousness is introduced to explain how the plethora of effects anesthetics have on cellular functioning ultimately all converge on a single neuroanatomic/neurophysiologic system, thus providing for a unitary physiologic theory of narcosis related to consciousness.
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