James G. Graham
University of Illinois at Chicago
44 Papers
549 Citations
James G. Graham is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Reductase & NAD(P)H Dehydrogenase (Quinone). The author has an hindex of 22, co-authored 42 publications. Previous affiliations of James G. Graham include Field Museum of Natural History & National Agrarian University.
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Papers
The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use.
Norman R. Farnsworth,E C Krause,Judy L. Bolton,Guido F. Pauli,Richard B. van Breemen,James G. Graham +5 more
TL;DR: The primary focus of this article is to describe the operation of the Center for Botanical Dietary Supplements Research, from acquiring and identifying botanicals to isolating and identifying active constituents, to elucidating their mechanisms of action, and to conducting phase I and phase II clinical studies.
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Activity-guided isolation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity
Bao Ning Su,Eun Jung Park,Dejan Nikolic,Bernard D. Santarsiero,Andrew D. Mesecar,Jose Schunke Vigo,James G. Graham,Fernando Cabieses,Richard B. van Breemen,Harry H. S. Fong,Norman R. Farnsworth,John M. Pezzuto,A. Douglas Kinghorn +12 more
TL;DR: Activity-monitored fractionation of a CHCl(3)-soluble extract of Deprea subtriflora using a quinone reductase induction assay led to the purification of subtrIfloralactones A-J (1-10), 10 novel C-18 norwithanolides based on a new C(27) skeleton.
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Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru
Fredyc Diaz,Hee Byung Chai,Qiuwen Mi,Bao Ning Su,Jose Schunke Vigo,James G. Graham,Fernando Cabieses,Norman R. Farnsworth,Geoffrey A. Cordell,John M. Pezzuto,Steven M. Swanson,A. Douglas Kinghorn +11 more
TL;DR: Cytotoxicity-based, bioassay-guided fractionation of the chloroform-soluble extracts of both the roots and leaves of Picramnia latifolia led to the isolation of two new anthrone C-glycosides, picramniosides G and H, and a new benzanthrone natural product.
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New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos
Bethany G. Elkington,Bethany G. Elkington,Kongmany Sydara,Andrew G. Newsome,CH Hwang,David C. Lankin,Charlotte Simmler,José G. Napolitano,Richard H. Ree,James G. Graham,James G. Graham,Charlotte Gyllenhaal,Somsanith Bouamanivong,Onevilay Souliya,Guido F. Pauli,Scott G. Franzblau,Djaja Djendoel Soejarto,Djaja Djendoel Soejarto +17 more
TL;DR: This research has helped to increase awareness of Laos' rich diversity of medicinal plants and will hopefully provide incentive to preserve the undeveloped forested areas that remain, which still hold a wealth of medical information for future discoveries.
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The NAPRALERT Database as an Aid for Discovery of Novel Bioactive Compounds
James G. Graham,Norman R. Farnsworth +1 more
- 01 Mar 2010
TL;DR: NAPRALERT contains data on the geography, taxonomy, chemistry, medicinal folklore, and biological activities of natural products, including clinical trials, of their extracts and isolates, and as such, represents a unique tool for the discovery of novel bioactive compounds.
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